BMJ Open:台湾同胞罹患骨关节炎会增加类风湿关节炎风险

2015-12-31 Seven L MedSci原创

研究者使用台湾全国性健康数据库进行了一项研究,探究症状性骨关节炎或骨关节炎相关手术患者类风湿关节炎发生风险。该全国性基于人群的病例对照研究共纳入了1147名20-100岁的类风湿性关节炎患者,以及5735名匹配的对照组参与者。研究者对所有参与者进行了长达14年的回顾性追踪,以识别骨关节炎或骨关节炎相关的手术情况。使用多元逻辑回归分析,以量化类风湿关节炎和骨关节炎之间的联系。研究数据显示,校正相关因

研究者使用台湾全国性健康数据库进行了一项研究,探究症状性骨关节炎或骨关节炎相关手术患者类风湿关节炎发生风险。

该全国性基于人群的病例对照研究共纳入了1147名20-100岁的类风湿性关节炎患者,以及5735名匹配的对照组参与者。

研究者对所有参与者进行了长达14年的回顾性追踪,以识别骨关节炎或骨关节炎相关的手术情况。使用多元逻辑回归分析,以量化类风湿关节炎和骨关节炎之间的联系。

研究数据显示,校正相关因素后,症状性骨关节炎患者类风湿关节炎发生风险增高 (aOR=5.24, p<0.001),骨关节炎相关手术患者类风湿关节炎发生风险同样增高 (aOR=2.27, p<0.001)。

该全国性基于人口的病例对照研究表明,台湾症状性骨关节炎患者其罹患类风湿关节炎风险增高。该结果也支持假说,遗传易感个体处于敏感环境时,骨性关节炎可能是类风湿性关节炎的触发因素。

原始出处:

Lu MC, Liu KC,et al.Higher incidence of rheumatoid arthritis in patients with symptomatic osteoarthritis or osteoarthritis-related surgery: a nationwide, population-based, case-control study in Taiwan.BMJ Open. 2015 Dec 18;5(12):e008513.

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    2016-05-04 lisa438
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    2016-09-29 gaoxiaoe
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    2016-08-07 feather89
  4. 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createdName=gaoxiaoe, createdTime=Thu Sep 29 06:36:00 CST 2016, time=2016-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725988, encodeId=db371e25988ae, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Aug 07 23:36:00 CST 2016, time=2016-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51125, encodeId=c0735112507, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Sat Jan 02 07:10:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51126, encodeId=fe865112667, content=不错哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=130, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Sat Jan 02 07:10:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51127, encodeId=72f25112eb2, content=赞一个, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRiaKicWybj5Q5KN7PWibALciaJ4W5bZwTlDSFRibFu87125pCq0IXePrC0mpbiasADRqL4NcjUoyQCT9De/0, createdBy=7c7e1636498, createdName=wzf990214, createdTime=Sat Jan 02 07:10:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1265277, encodeId=976812652e711, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Sat Jan 02 06:36:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1333788, encodeId=6b9c1333e8899, content=<a href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sat Jan 02 06:36:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597242, encodeId=3c87159e242db, content=<a href='/topic/show?id=fa1710082017' target=_blank style='color:#2F92EE;'>#风湿关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100820, encryptionId=fa1710082017, topicName=风湿关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=456818510265, createdName=xuruicheng, createdTime=Sat Jan 02 06:36:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51051, encodeId=0cb1510519b, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Fri Jan 01 22:30:00 CST 2016, time=2016-01-01, status=1, ipAttribution=)]
    2016-01-02 wzf990214

    有意思

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2026506, encodeId=13ba20265063b, content=<a href='/topic/show?id=e0b110159578' target=_blank style='color:#2F92EE;'>#骨关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101595, encryptionId=e0b110159578, topicName=骨关节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Wed May 04 20:36:00 CST 2016, time=2016-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847831, encodeId=353d184e831fb, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, createdName=gaoxiaoe, createdTime=Thu Sep 29 06:36:00 CST 2016, time=2016-09-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1725988, encodeId=db371e25988ae, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Sun Aug 07 23:36:00 CST 2016, time=2016-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51125, encodeId=c0735112507, content=有意思, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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href='/topic/show?id=5306e6164b6' target=_blank style='color:#2F92EE;'>#类风湿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76164, encryptionId=5306e6164b6, topicName=类风湿)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eq2AGzrugK9ZUjU3eJxzM901ophWib0xJDrSicy49ibWl3zB5pbDto7eoR6tnzwOiaKdbq1a8PcbYFFrw/132, createdBy=6ff22500098, createdName=ms4964546379600229, createdTime=Sat Jan 02 06:36:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597242, encodeId=3c87159e242db, content=<a href='/topic/show?id=fa1710082017' target=_blank style='color:#2F92EE;'>#风湿关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100820, encryptionId=fa1710082017, topicName=风湿关节炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=456818510265, createdName=xuruicheng, createdTime=Sat Jan 02 06:36:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51051, encodeId=0cb1510519b, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Fri Jan 01 22:30:00 CST 2016, time=2016-01-01, status=1, ipAttribution=)]
    2016-01-02 wzf990214

    不错哦

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2026506, encodeId=13ba20265063b, content=<a href='/topic/show?id=e0b110159578' target=_blank style='color:#2F92EE;'>#骨关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101595, encryptionId=e0b110159578, topicName=骨关节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Wed May 04 20:36:00 CST 2016, time=2016-05-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1847831, encodeId=353d184e831fb, content=<a href='/topic/show?id=2977356edc' target=_blank style='color:#2F92EE;'>#BMJ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3567, encryptionId=2977356edc, topicName=BMJ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=148754, 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authenticateStatus=null, createdAvatar=null, createdBy=456818510265, createdName=xuruicheng, createdTime=Sat Jan 02 06:36:00 CST 2016, time=2016-01-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=51051, encodeId=0cb1510519b, content=牛, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7cde98330, createdName=milkshark, createdTime=Fri Jan 01 22:30:00 CST 2016, time=2016-01-01, status=1, ipAttribution=)]
    2016-01-02 wzf990214

    赞一个

    0

  7. 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    2016-01-02 lmm397
  8. 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  9. 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  10. 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    2016-01-01 milkshark

    0

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ACR 2015:日常饮食可影响类风湿关节炎的发生?

本周发表在美国旧金山风湿病年度会议的两项研究,表现出一个人的饮食可以显著影响人们发生类风湿关节炎的几率。类风湿性关节炎是最常见的影响关节的慢性自体免疫疾病。RA可以使关节损伤和变形,并且具有功能丧失的可能性。RA的原因未知。它影响所有年龄的人,而女性更普遍比男性多。RA会引起疼痛,僵硬和肿胀,通常在多个关节发生。RA可能会影响到任何关节,但手和脚的小关节最常受累。类风湿炎症也可能发展其他器官如肺。

BMJ:近期感染降低类风湿关节炎患病风险

近期感染影响类风湿关节炎(RA)患病风险吗?读完这篇研究告诉你答案。研究者使用基于人群的个体控制研究EIRA(n=6401),以观察和健康对照组相比,RA的发病风险。该研究对研究对象按照性别、年龄、时间、居住地区域进行匹配。入组前的两年内有无发生胃肠炎、尿路感染、生殖器感染、前列腺炎、鼻窦炎、扁桃体炎、肺炎的感染情况被统计记录,使用假设Logistic 回归分析来计算OR值,吸烟情况和社会经济地位

PLoS One:类风湿关节炎患者易并发慢性肾病

背景和目的:有关类风湿关节炎(RA)与慢性肾疾病(CKD)和血管球形肾炎关系的大型人群基础研究较少。这项全国性的队列研究调查RA患者形成CKD和血管性球形肾炎的风险,以及心血管并发症的相关风险。方法:研究人员从台湾国家健康保险研究数据库选取12579名RA患者,随机选取37737名无RA的受试者作为对照组。对其随访5年,应用Cox比例风险回归模型分析发生CKD的风险。结果:在随访期间,校正传统心血

招募女性类风湿关节炎患者参加临床试验

类风湿关节炎是一种以侵蚀性关节炎为主要表现的全身性自身免疫病。本病以女性多发,我国大陆地区的类风关患病率约为0.2%~0.4%。 本病表现为以双手和腕关节等小关节受累为主的对称性、持续性多关节肿胀和疼痛,常伴有晨僵。受累关节以近端指间关节,掌指关节,腕、肘和足趾关节最为多见;同时,颈椎、颞颌关节、胸锁和肩锁关节也可受累。中、晚期的患者可出现手指的“天鹅颈”及“钮

Ann Rheum Dis:阿达木单抗诱导治疗类风湿关节炎的临床和影像学结果

目标:研究1年前经阿达木单抗诱导药治疗的早期类风湿关节炎病人的临床和影像学结局,另加以甲氨蝶呤和关节内糖皮质激素的针对性治疗策略。方法:早期类风湿关节炎病人以改变病情抗风湿药(DMARD)的甲氨蝶呤(20mg每周)与关节内糖皮质激素(20 mg/ml)治疗2年。另外,在第一年随机将他们分配到阿达木单抗诱导安慰剂组(予以单抗诱导安慰剂,n=91)和阿达木单抗诱导组(40 mg每隔一周)(予以阿达木单

Annals of the Rheumatic Diseases:新发现:新的血液测试可以提前16年诊断类风湿性关节炎!

科学家们发现了一个标记,可以预测你发生类风湿关节炎(RA)的可能性,甚至在发生十六年之前进行预测。来自牛津大学甘乃迪风湿病学研究所的一个研究小组发现,血液测试,可以找到识别看肌腱蛋白-C的抗体,可以可靠地显示哪些抗体可以可以导致该病的发生。当炎症发生于体内时,在一个叫做瓜氨酸化的过程中一些蛋白质被改变。这些改变的形式可以促使身体发生免疫反应,这可以看成是它开启抗体本身的免疫反应-导致风湿性关节炎。