JAHA:急性和连续血小板功能测定在急性缺血性脑卒中的临床意义!

2018-06-02 xing.T MedSci原创

由此可见,这些结果提示缺血性卒中急性期HAPR增加了随后的血管事件的风险,并且连续的阿司匹林反应单位测量可以确定血管事件风险较高的急性缺血性卒中患者。额外的研究是必要的,以确定HAPR的急性缺血性脑卒中患者适当的治疗手段。

近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章。研究人员旨在调查急性缺血性脑卒中患者急性期血小板对阿司匹林的反应性以及血小板对阿司匹林反应性变化对血管事件风险的临床意义。

这是一项单中心、前瞻性、观察性研究。阿司匹林反应单位分别盲目测量两次:阿司匹林负荷3小时后和阿司匹林给药后第5天。高阿司匹林血小板反应性(HAPR)被定义为阿司匹林反应单位超过550 IU。该研究的主要结局指标包括卒中、心肌梗死和血管死亡的1年复合事件。

研究人员共对805例患者(年龄为66±12岁,男性占61%)进行了分析。805例患者中有99例(12.3%)和558例患者中有78例(14%)分别在服用阿司匹林第5天和阿司匹林负荷3小时后出现HAPR。在阿司匹林给药第5天时,HAPR与对阿司匹林血小板反应性正常的患者相比1年内发生血管事件的风险更大。在阿司匹林给药第5天的HAPR与1年内发生血管事件独立相关(风险比为1.84;95%可信区间为1.07-3.19)。此外,持续HAPR显著增加了1年内血管事件的风险(风险比为3.11;95%可信区间为1.23-7.86)。

由此可见,这些结果提示缺血性卒中急性期HAPR增加了随后的血管事件的风险,并且连续的阿司匹林反应单位测量可以确定血管事件风险较高的急性缺血性卒中患者。额外的研究是必要的,以确定HAPR的急性缺血性脑卒中患者适当的治疗手段。

原始出处:


Joon‐Tae Kim,et al. Clinical Significance of Acute and Serial Platelet Function Testing in Acute Ischemic Stroke, JAHA.2018. https://doi.org/10.1161/JAHA.117.008313

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    2018-06-04 zhaohui6731
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    2018-06-02 易水河

    学习学习了

    0

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    2018-06-02 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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