JAHA:抗抑郁药、抑郁症和静脉血栓栓塞风险!

2017-05-18 xing.T MedSci原创

由此可见,在英国妇女中抗抑郁药的使用是普遍存在的,并且与VTE的风险增加相关。

一些研究者已经报告了静脉血栓栓塞症(VTE)的过量风险与抑郁症和使用抗抑郁药物相关。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员在英国女性中一个大型前瞻性研究中探讨了这些相关性。

百万妇女研究通过在英国和苏格兰的国家卫生服务乳腺筛查计划中招募了130万名妇女。招募后三年,这些妇女被分发第二份调查问卷,以询问在过去的4个星期内抑郁症和经常使用的药物情况。目前的分析包括了那些有反应且之前没有VTE、癌症或最近手术的患者。研究人员通过链接到常规收集的国家卫生服务统计数据来进行VTE随访,并采用Cox回归分析得出调整后的风险比和95%可信区间。

共有734092名女性(平均年龄为59.9岁)被纳入分析;6.9%的女性报告使用了抗抑郁药物,2.7%的女性报告使用了其他精神类药物,1.8%的女性报告了接受过针对抑郁症或焦虑的治疗,但不使用精神类药物。在随访的平均7.3年期间,有3922名妇女因VTE而住院或死亡。报告了使用过抗抑郁药物的女性发生VTE的风险显著高于那些报告既未发生抑郁症也未使用过精神类药物的女性(风险比为1.39;95%可信区间为1.23-1.56)。在那些报告了接受过针对抑郁症或焦虑的治疗,但未使用抗抑郁药或其他精神类药物的女性中,VTE的风险并没有显著增加(风险比为1.19;95%可信区间为0.95-1.49)。

由此可见,在英国妇女中抗抑郁药的使用是普遍存在的,并且与VTE的风险增加相关。

原始出处:


Lianne Parkin, et al. Antidepressants, Depression, and Venous Thromboembolism Risk: Large Prospective Study of UK Women.JAHA.2017. https://doi.org/10.1161/JAHA.116.005316

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    2018-04-08 fusion
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authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Jun 07 07:25:40 CST 2017, time=2017-06-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200446, encodeId=a4b3200446f9, content=学习了。。。。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Sat May 20 14:21:01 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492174, encodeId=6ddc14921e43e, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Sat May 20 13:23:00 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267445, encodeId=22c1126e445b9, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sat May 20 13:23:00 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200255, encodeId=679420025520, content=抑郁症现在越来越多了,应该多注意, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat May 20 07:04:53 CST 2017, time=2017-05-20, status=1, ipAttribution=)]
    2018-02-14 xue8602
  5. 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objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Sat May 20 13:23:00 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267445, encodeId=22c1126e445b9, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sat May 20 13:23:00 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200255, encodeId=679420025520, content=抑郁症现在越来越多了,应该多注意, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat May 20 07:04:53 CST 2017, time=2017-05-20, status=1, ipAttribution=)]
    2017-06-18 jyzxjiangqin

    考虑周到全面。

    0

  6. 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content=抑郁症现在越来越多了,应该多注意, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat May 20 07:04:53 CST 2017, time=2017-05-20, status=1, ipAttribution=)]
    2017-06-07 jyzxjiangqin

    药物间的相互作用。

    0

  7. 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content=抑郁症现在越来越多了,应该多注意, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat May 20 07:04:53 CST 2017, time=2017-05-20, status=1, ipAttribution=)]
    2017-05-20 135****7952平儿

    学习了。。。。。。。

    0

  8. 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  9. 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content=抑郁症现在越来越多了,应该多注意, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Sat May 20 07:04:53 CST 2017, time=2017-05-20, status=1, ipAttribution=)]
    2017-05-20 zhaohui6731
  10. 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    2017-05-20 清风拂面

    抑郁症现在越来越多了,应该多注意

    0

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此前,有一些研究已经评估了孕妇产前接触抗抑郁药和儿童自闭症谱系障碍(ASD)之间的联系,但是研究结果不一致,特别是关于孕前三个月药物暴露后的影响。近期,一项发表在杂志JAMA Pediatr上的研究进行系统评价,并对已发表的研究进行荟萃分析,以评估ASD与孕前及怀孕期间胎儿暴露于抗抑郁药之间的关系。研究者们收集了截至2016年5月的PubMed、EMBASE和PsycINFO数据库中的观察性研究。

加拿大学者发现服用抗抑郁药可能加倍增加患痴呆症的风险

加拿大萨斯喀彻温大学的研究人员采用医学文献研究方法,发现位列全球处方药前列的抗抑郁药,有可能助长阿尔茨海默症和其他脑损伤痴呆症的发生。研究团队利用医学文献研究方法,对4123篇医学文章进行筛选,最后选择出5篇符合他们研究标准的文章,这5篇文章共涉及约150万人。

J Am Acad Child Psy:非典型抗精神病药与抗抑郁药合用增加糖尿病风险!

用非典型抗精神病药(AAP)治疗的青少年的一半以上同时服用抗抑郁药或兴奋剂。本研究评估了服用AAPs的同时使用抗抑郁药或兴奋剂与2型糖尿病(T2DM)风险之间的联系。

研究表明:“标签外”抗抑郁药不具有科学依据

科学家表示,大部分“标签外”(未在药品许可证所列适应症范围内)使用的抗抑郁药不能使药物达到预期效果。研究人员在医学期刊《英国医学杂志》(BMJ)中也提到,在这种“标签外”治疗中,仅有一小部分被检测了其功效及副作用。