Chest:慢性鼻窦炎是世贸中心救援者阻塞性睡眠呼吸暂停的独立危险因素

2018-10-26 xing.T MedSci原创

由此可见,肥胖和性别没有充分解释WTC救援者中OSA的高患病率。CRS受试者OSA风险升高的可能机制包括上呼吸道炎症增加和/或鼻部/上呼吸道阻力升高,但需要进一步确认。

在参与世界贸易中心救援和恢复工作人员中,经常报告阻塞性睡眠呼吸暂停症(OSA)症状,许多呼吸系统疾病都归因于有毒粉尘和烟雾暴露。近日,呼吸领域权威杂志chest上发表了一篇研究文章,研究人员评估了新发OSA的患病率,并检测了OSA的患病率和严重程度是否与慢性鼻窦炎(CRS)有关。

参加世贸中心健康计划的601名受试者(男性占83%,年龄为33-87岁,体重指数=29.9±5.5公斤/平方米),不包括那些在2001年9月11日之前(9/11)打鼾或之前的CRS患者,进行了2晚的家庭睡眠检查。OSA定义为AHI4%≥5/hr或RDI≥15/hr。研究人员使用鼻部症状调查表评估了CRS。

OSA的患病率为75%(25%无OSA,46%为轻度,19%为中度和10%为严重OSA),CRS为43.5%。与无CRS相比,新发和恶化的CRS是OSA的重要危险因素,未调整的比值比为1.80(1.18-2.73),p=0.006;调整年龄、BMI、性别、GERD和饮酒后,比值比为1.76(1.08-2.88),p= 0.02。

由此可见,肥胖和性别没有充分解释WTC救援者中OSA的高患病率。CRS受试者OSA风险升高的可能机制包括上呼吸道炎症增加和/或鼻部/上呼吸道阻力升高,但需要进一步确认。

原始出处:

Jag Sunderram,et al.Chronic Rhinosinusitis is an independent risk factor for Obstructive Sleep Apnea in World Trade Center Responders.chest.2018. https://doi.org/10.1016/j.chest.2018.10.015

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    2018-10-28 花花1375
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channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Thu Feb 28 01:58:00 CST 2019, time=2019-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352020, encodeId=db7135202097, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Nov 09 09:50:50 CST 2018, time=2018-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351387, encodeId=797b135138ee5, content=<a 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350606, encodeId=6ba935060611, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Oct 26 23:51:06 CST 2018, time=2018-10-26, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=2037189, encodeId=1411203e189bf, content=<a href='/topic/show?id=9be468126d4' target=_blank style='color:#2F92EE;'>#独立危险因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68126, encryptionId=9be468126d4, topicName=独立危险因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Tue Dec 04 13:58:00 CST 2018, time=2018-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685237, encodeId=e05d168523e6b, content=<a href='/topic/show?id=f9b45e56606' target=_blank style='color:#2F92EE;'>#救援#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57566, encryptionId=f9b45e56606, topicName=救援)], attachment=null, authenticateStatus=null, createdAvatar=null, 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channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Thu Feb 28 01:58:00 CST 2019, time=2019-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352020, encodeId=db7135202097, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Nov 09 09:50:50 CST 2018, time=2018-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351387, encodeId=797b135138ee5, content=<a href='/topic/show?id=be7453e38d2' target=_blank style='color:#2F92EE;'>#慢性鼻窦炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53738, encryptionId=be7453e38d2, topicName=慢性鼻窦炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Oct 28 12:58:00 CST 2018, time=2018-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596550, encodeId=aa801596550fc, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Sun Oct 28 12:58:00 CST 2018, time=2018-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350606, encodeId=6ba935060611, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Oct 26 23:51:06 CST 2018, time=2018-10-26, status=1, ipAttribution=)]
    2019-04-05 tomyang96
  6. 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channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Thu Feb 28 01:58:00 CST 2019, time=2019-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352020, encodeId=db7135202097, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Nov 09 09:50:50 CST 2018, time=2018-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351387, encodeId=797b135138ee5, content=<a href='/topic/show?id=be7453e38d2' target=_blank style='color:#2F92EE;'>#慢性鼻窦炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53738, encryptionId=be7453e38d2, topicName=慢性鼻窦炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Oct 28 12:58:00 CST 2018, time=2018-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596550, encodeId=aa801596550fc, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Sun Oct 28 12:58:00 CST 2018, time=2018-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350606, encodeId=6ba935060611, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Oct 26 23:51:06 CST 2018, time=2018-10-26, status=1, ipAttribution=)]
    2019-02-28 Smile2680
  7. 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channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Thu Feb 28 01:58:00 CST 2019, time=2019-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352020, encodeId=db7135202097, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Nov 09 09:50:50 CST 2018, time=2018-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351387, encodeId=797b135138ee5, content=<a href='/topic/show?id=be7453e38d2' target=_blank style='color:#2F92EE;'>#慢性鼻窦炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53738, encryptionId=be7453e38d2, topicName=慢性鼻窦炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Oct 28 12:58:00 CST 2018, time=2018-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596550, encodeId=aa801596550fc, content=<a href='/topic/show?id=70e4396491a' target=_blank style='color:#2F92EE;'>#呼吸暂停#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=39649, encryptionId=70e4396491a, topicName=呼吸暂停)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e2a518392360, createdName=119337463, createdTime=Sun Oct 28 12:58:00 CST 2018, time=2018-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350606, encodeId=6ba935060611, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Oct 26 23:51:06 CST 2018, time=2018-10-26, status=1, ipAttribution=)]
    2018-11-09 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

  8. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350606, encodeId=6ba935060611, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Oct 26 23:51:06 CST 2018, time=2018-10-26, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=2037189, encodeId=1411203e189bf, content=<a href='/topic/show?id=9be468126d4' target=_blank style='color:#2F92EE;'>#独立危险因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=68126, encryptionId=9be468126d4, topicName=独立危险因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3516494, createdName=spoonycyy, createdTime=Tue Dec 04 13:58:00 CST 2018, time=2018-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1685237, encodeId=e05d168523e6b, content=<a href='/topic/show?id=f9b45e56606' target=_blank style='color:#2F92EE;'>#救援#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57566, encryptionId=f9b45e56606, topicName=救援)], attachment=null, authenticateStatus=null, createdAvatar=null, 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channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4625, encryptionId=9e604625ab, topicName=Chest)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c48a270, createdName=Smile2680, createdTime=Thu Feb 28 01:58:00 CST 2019, time=2019-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=352020, encodeId=db7135202097, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Fri Nov 09 09:50:50 CST 2018, time=2018-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351387, encodeId=797b135138ee5, content=<a 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350606, encodeId=6ba935060611, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Oct 26 23:51:06 CST 2018, time=2018-10-26, status=1, ipAttribution=)]
  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=350606, encodeId=6ba935060611, content=了解一下,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Oct 26 23:51:06 CST 2018, time=2018-10-26, status=1, ipAttribution=)]
    2018-10-26 天地飞扬

    了解一下,谢谢分享!

    0

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背景慢性鼻窦炎(CRS)、过敏性鼻炎(AR)和鼻中隔偏差(NSD)这些频繁发生的慢性疾病要消耗相当大的医疗资源并增加民众的经济负担。 目的该研究的目的在于确定韩国民众患慢性鼻窦炎(CRS)、过敏性鼻炎(AR)和鼻中隔偏差(NSD)的患病率和相关风险因素。 设计研究人员从2008-2012年韩国国家健康和营养调查研究(KNHANES)中提取出相关数据进行分析。共有35511参与者接受访谈,主要内容为

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据一项新的研究报告,鼻腔中微生物群的改变可能会触发慢性鼻窦问题。到目前为止,对鼻窦感染的治疗的目的一直是要将细菌从鼻窦中消除。然而,这些发现提示,在鼻窦中重新植入细菌可能对慢性鼻窦炎患者有益。Nicole Abreu及其同事对一小组接受了矫正性鼻腔手术的慢性鼻窦炎患者以及一组没有鼻窦问题但却因为与鼻窦无关的问题而接受手术的病人的微生物群落概况进行了检测。由于这些菌落中的大部分的细菌无法在常规的实验

Clin Exp Allergy:家中空气湿度也许是慢性鼻窦炎的一个风险因子

在儿童群体中,人们已经明确的阐释了家中空气湿度与呼吸道条件的关系。但是,在成人中相关的研究很少,并且关于慢性鼻窦炎(CRS)的数据仍旧匮乏。CRS在欧洲具有10.9%患病率,具有显著的生活质量和经济负担。最近,有研究人员在一个代表性的成人群体样本中研究了CRS和其他呼吸条件与家中湿度的关系。瑞典GA2 LEN调查问卷的回复有26577名成年人(16到75岁),并且包含了关于呼吸道症状、抽烟、教育和

Int Forum Allergy Rhinol:中鼻甲的部分切除不会导致空鼻综合症风险的增加

慢性鼻窦炎(CRS)鼻内镜手术(ESS)过程中中鼻甲(MT)的处理仍旧是一个具有争议性的话题。最近,有研究人员调查了在ESS期间部分切除MT(PMTR)的临床影响,尤其关注了发展为空鼻综合症的风险和嗅觉改变情况。研究基于前瞻性搜集的数据。研究包括了177名患有CRS而经历ESS的患者。其中包括93名PMTR患者和MT保留(MTP)患者。研究发现,在PMTR和MTP患者比较中,空鼻综合症6项问卷(E

Rhinology:伊朗西南部地区布什尔慢性鼻窦炎流行病学研究

利用慢性鼻窦炎和鼻息肉(EPOS)欧洲标准来评估基于群体的慢性鼻窦炎(CRS)流行度在公众健康政策的发展和促进过程中具有重要的作用。最近,有研究人员在伊朗西南部地区布什尔,进行了 一个多阶段、分层聚类和随机抽样的方法从当地的居民中选择了研究的参与者。研究总共有5201名参与者完成了标准化的全球过敏和哮喘欧洲网络(GA2LEN)调查问卷,并利用卡方测试比较了具有不同相关因素下的CRS流行度。研究发现

Am J Rhinol Allergy:慢性鼻窦炎与代谢综合征的关系

最近,有研究人员调查了代谢综合征与慢性鼻窦炎(CRS)的关系,并且根据来源自韩国国民健康与营养检查调查(KNHANES)的数据调查了CRS相关的风险因子。KNHANES调查的个体年龄均大于19岁,调查时间为2010年1月到2011年12月。CRS包含"基于症状的CRS",由欧洲白皮书关于鼻窦炎和鼻息肉2012定义。代谢综合征根据美国心脏协会/国家心肺和血液研究标准诊断。并且进行了 χ2分析、单变量