Clinica Chimica Acta:中国冠心病患者残余胆固醇水平的比较

2020-02-18 MedSci MedSci原创

关于残余胆固醇(RC),尤其是非空腹RC,是否是中国受试者冠心病(CHD)的一个因果危险因素的证据很少。近年来,估计RC水平(RCe)被应用于许多大样本的研究中。本研究旨在比较中国受试者不同方法测定的LDL-C水平计算的空腹和非空腹RCe,并探讨其对冠心病的贡献。

关于残余胆固醇(RC),尤其是非空腹RC,是否是中国受试者冠心病(CHD)的一个因果危险因素的证据很少。近年来,估计RC水平(RCe)被应用于许多大样本的研究中。本研究旨在比较中国受试者不同方法测定的LDL-C水平计算的空腹和非空腹RCe,并探讨其对冠心病的贡献。

在每日早餐之前和之后4小时,直接在273CHD患者(CHD组)和136个对照组(CON组)中直接测量TCTGHDL-C的水平。直接测量或通过Friedewald方程在TG <4.5 mmol / L下计算LDL-C水平。 通过计算或测量的LDL-C估算的RC水平称为RCe1RCe2。通过多变量逻辑回归分析评价不同RC水平对冠心病的贡献。

研究结果表明,4 h早餐后RCe1RCe2显著增加 (p < 0.05)。禁食或非空腹状态RCe1显著高于RCe2 (p < 0.05)RCe1 RCe2密切相关,特别是在最高四分位数的RCe1 (p < 0.05)。校正整传统危险因素后,非禁食RCe1RCe2和禁食RCe2独立预测冠心病(所有p <0.05)。

研究结果表明,虽然RCe1明显高于RCe2,但无论是RCe1还是RCe2,每日早餐后的非空腹状态都是中国受试者CHD风险的独立预测因子,表明非空腹状态在动脉粥样硬化的发展中至关重要。

原始出处:

Qun-yan XiangFeng TianComparison of remnant cholesterol levels estimated by calculated and measured LDL-C levels in Chinese patients with coronary heart disease

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    2020-06-10 windight
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