Clin Gastroenterology H: 幽门螺杆菌暴露与嗜酸性食管炎几率降低之间的关联

2019-10-21 不详 MedSci原创

据报道,先前或当前感染幽门螺杆菌可预防嗜酸性食管炎(EoE)的发生,可能是由于幽门螺杆菌引起的自身免疫调节导致的。本项研究旨在通过荟萃分析更清楚地评估幽门螺杆菌暴露与EoE 之间的关联。

背景与目标
据报道,先前或当前感染幽门螺杆菌可预防嗜酸性食管炎(EoE)的发生,可能是由于幽门螺杆菌引起的自身免疫调节导致的。本项研究旨在通过荟萃分析更清楚地评估幽门螺杆菌暴露与EoE 之间的关联。

方法
研究人员搜索了4个大型数据库,以确定暴露于幽门螺杆菌(暴露)的个体与经测试发现是否患有幽门螺杆菌的个体之间的EoE(主要结果)或食道嗜酸性粒细胞增多(次要结果)的可能性或风险。元回归和敏感性分析是事先计划好的。同时研究人员对研究进行了质量,偏倚和异质性评估。

结果
总共有11项观察性研究纳入本项研究,包括有关全球377795位病患的数据。幽门螺杆菌暴露与未暴露相比,EoE几率降低37%(风险比:0.63; 95%CI:0.51-0.78),食管嗜酸粒细胞增多几率降低38%(风险比:0.62; 95%CI:0.52-0.76)。 与回顾性研究相比,前瞻性研究发现幽门螺杆菌暴露与EoE 之间存在显着关联(P = .06)。效果评估不受研究位置的影响。

结论
研究人员发现幽门螺杆菌暴露与EoE降低几率之间显着相关。

原始出处:

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    2019-12-24 许安
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    2020-08-13 zhouqu_8
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    2019-12-29 kcb069
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    2019-10-23 zhouqu_8
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