JAMA:孕前体重、孕期增重与母婴结局

2019-05-10 MedSci MedSci原创

研究发现,孕妇和婴儿不良结局的风险因妊娠体重增加和孕前体重范围不同而不同。

妊娠期体重增加过少或过多均与母婴不良结局有关,近日研究人员就妊娠期体重增加范围与母婴不良结局风险的关系进行了考察。

研究人员采用来自欧洲和北美25项队列研究(主要研究样本)中196 670名参与者的数据进行个体参与者水平的荟萃分析。通过选择妊娠期体重增加的范围来评估每个怀孕前体重指数(BMI)类别的最佳妊娠期增重范围,该范围与任何不良结果的风险较低有关。主要终点为任何不良结局,定义为出现以下1种或1种以上结局:先兆子痫、妊娠高血压、妊娠糖尿病、剖宫产、早产和出生时的婴儿的体型小于或大于胎龄。

196 670名妇女,中位年龄30岁,7809人(4.0%)被归类为体重不足(BMI<18.5),133 788人(68.0%)正常体重(BMI:18.5-24.9),38 828人(19.7%)超重(BMI:25.0-29.9),992人(6.1%)肥胖1级(BMI 30.0-34.9), 3284人(1.7%)肥胖2级(BMI 35-39.9),969人(0.5%)肥胖3级(BMI≥40)。总体上,37.2%(n=73161)的妇女出现任何不良结果,其中34.7%(7809人中的2 706人)属于体重不足的妇女,61.1%(969人中的5 92人)属于肥胖三级。妊娠期最佳增重范围为:体重不足妇女为14.0kg~16.0kg,正常体重妇女为10.0kg~18.0kg,超重妇女为2.0kg~16.0kg,肥胖1级妇女为2.0kg~6.0kg,肥胖2级减重或增重0~4.0kg,肥胖3级增重0~6.0kg,这些妊娠期增重幅度与有不良结果者和无不良结局者之间有低到中等的相关性(操作特征曲线下面积范围,0.5~0.76),验证样本与研究样本的结果相似(操作特征曲线下面积,0.51~0.79)。

研究发现,孕妇和婴儿不良结局的风险因妊娠体重增加和孕前体重范围不同而不同。

原始出处:

LifeCycle Project-Maternal Obesity and Childhood Outcomes Study Group. Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes. JAMA. May 7,2019.

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    2020-04-15 szhvet
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