Gastric Cancer:胃癌胃切除术后非酒精性脂肪肝的危险因素

2019-12-16 不详 网络

非酒精性脂肪肝疾病(NAFLD)是指除酒精性肝损伤以外的其他原因引起的肝脂肪变性,通常发生在胃肠道手术(如胰十二指肠切除术和胃切除术)之后。本研究旨在确定胃癌胃切除术后发生NAFLD的危险因素。

背景
非酒精性脂肪肝疾病(NAFLD)是指除酒精性肝损伤以外的其他原因引起的肝脂肪变性,通常发生在肠道手术(如胰十二指肠切除术和切除术)之后。本研究旨在确定胃癌胃切除术后发生NAFLD的危险因素。

方法
本研究共包括721例术前和术后1年因胃癌和平面腹部CT进行胃切除术的患者。NAFLD被定义为平均肝CT衰减值小于40个单位。研究人员回顾性检查了NAFLD发作与临床病理结果之间的关系,以确定与胃切除术后NAFLD发生相关的危险因素。

结果
术后NAFLD的发生率为4.85%(35/721)。单因素分析确定了以下因素与NAFLD的发生显着相关:年龄,术前BMI≥25 kg/m2,肿瘤深度pT3≤,pN2≤淋巴结转移等级,胆囊切除术,D2淋巴结清扫术,辅助化疗,术前胆碱酯酶血清水平高,术前FIB-4指数低。胃切除术后1年,辅助化疗(p<0.001)和术前胆碱酯酶血清水平高(p = 0.021)被确定为NAFLD的独立危险因素。

结论
本项研究表明S-1辅助化疗和高水平的血清胆碱酯酶被认为是胃癌胃切除术后发生NAFLD的危险因素。

原始出处:

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    2020-10-27 skhzy
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    2020-05-03 许安
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    2019-12-18 bshuang

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