EMBO Reports：中科院科学家揭示细胞自噬活性的调控机制

2014-06-24 佚名不详

中科院生物物理所张宏实验室在EMBO Reports上发表题为"Genome‐wide screen identifies signaling pathways that regulate autophagy during Caenorhabditis elegans development"的文章。本研究发现核糖体大亚基蛋白RPL-43功能缺失会导致SQST-1（哺乳动物细胞p62同源物）蛋

中科院生物物理所张宏实验室在EMBO Reports上发表题为"Genome‐wide screen identifies signaling pathways that regulate autophagy during Caenorhabditis elegans development"的文章。

本研究发现核糖体大亚基蛋白RPL-43功能缺失会导致SQST-1（哺乳动物细胞p62同源物）蛋白聚集体在线虫肠道细胞中累积。这些累积的蛋白聚集体能够被上调的细胞自噬活性有效降解。以此为模型，张宏实验室进行了线虫全基因组RNAi筛选，发现了139个基因功能缺失能有效地上调细胞自噬活性，从而促进rpl-43突变体中累积的SQST-1蛋白聚集体的降解。进一步研究发现许多发育信号转导通路，包括Sma/Mab TGF-β信号通路、lin-35/Rb信号通路、XBP-1介导的内质网应激信号通路以及ATFS-1介导的线粒体应激信号通路能够在转录水平调控细胞自噬基因的表达。这项研究工作为人们深入理解各种信号转导通路在生理条件下如何调节细胞自噬活性提供一个框架。

原始出处

Guo B1, Huang X2, Zhang P3, Qi L3, Liang Q3, Zhang X2, Huang J3, Fang B3, Hou W3, Han J3, Zhang H4.Genome-wide screen identifies signaling pathways that regulate autophagy during Caenorhabditis elegans development.EMBO Rep. 2014 Jun

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2014-09-16 gous

#中科院#

32 0
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2015-01-13 huirong

#自噬活性#

40 0
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2014-06-26 FukaiBao

#细胞自噬#

36 0
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2014-06-26 villahu

#调控机制#

46 0

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