Science：肠道菌群——使坏的真菌！

2018-01-12 Juka 转化医学网

在以往的研究中，我们发现免疫系统、肠道菌群以及肠道疾病有着非比寻常的联系。然而在过往的研究中，我们的目光往往投射在肠道菌群的细菌群体中，却忽视了肠道中还存在着另一种菌群：真菌菌群。

在以往的研究中，我们发现免疫系统、肠道菌群以及肠道疾病有着非比寻常的联系。然而在过往的研究中，我们的目光往往投射在肠道菌群的细菌群体中，却忽视了肠道中还存在着另一种菌群：真菌菌群。

而来自 Weill Cornell Medicine 的科学家们在1月11号的最新一期的《Science》上面发表了名为“CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi”的文章，就阐明了免疫细胞、肠道真菌和克罗恩病以及其他肠道疾病（IBD）之间的关系，为我们治疗肠道疾病打开了另一扇新的大门。

免疫系统有着一套自己的方法识别肠道中可以和人类互利共生的肠道菌群，然而一旦这种方法失效，免疫系统开始攻击肠道菌群，人类的一些肠道疾病就会浮现出来。在最新的研究中，科研人员发现：在肠道中，有着专门调节肠道真菌的机制：白细胞CX3CR1 +单核吞噬细胞。

当小鼠发生结肠炎的时候，再向小鼠肠道中添加真菌，结果发现小鼠的结肠炎更加严重。缺乏肠道白细胞CX3CR1 +吞噬细胞的小鼠比仍具有抗真菌细胞的小鼠更容易患肠病。在缺乏CX3CR1 +吞噬细胞的小鼠中，抗真菌药物治疗显着地逆转了疾病的征兆，这表明真菌过度生长是导致结肠炎的主要原因。而在接下来进行的人类克罗恩病患者中进行实验的时候，也发现了相同的情况。

早在2012年，该研究就已经在《Science》上面发表过研究表明肠道真菌可能和肠道疾病有着某种联系，而在如今，肠道真菌和肠道疾病的关系终于被解开。

研究的主要作者Iliyan Iliev博士说道：“我们的研究揭示了肠道真菌对于肠道疾病的作用。而当我们发现患者有该种基因（CX3CR1 +）的突变时候，我们可以现有的诊断方法确定我们的患者是否可以从抗真菌的药物治疗中获益。”

原始出处：

Irina Leonardi，et al.，CX3CR1+ mononuclear phagocytes control immunity to intestinal fungi.Science.12 Jan 2018：Vol. 359， Issue 6372， pp. 232-236.

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2018-01-28 1209e435m98(暂无昵称)

学习了.谢谢分享

47 0
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2018-01-21 1209e435m98(暂无昵称)

学习了.谢谢分享

66 0
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2018-01-17 1209e435m98(暂无昵称)

学习了.谢谢分享

46 0
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2018-01-14 zhaojie88

#真菌#

25 0
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createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIJiaCLWwZ60RaAUTVZeItKTcsUicNPFHRB64Bo60Rk8ICbaZCX5YcWrz5kgZqEH8UiaxuECuUufYmZg/132, createdBy=01cb2245548, createdName=呦呦517383645, createdTime=Sat Jan 13 01:34:48 CST 2018, time=2018-01-13, status=1, ipAttribution=)]
2018-01-14 jichang

#SCIE#

20 0
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17:30:57 CST 2018, time=2018-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277981, encodeId=51ba2e798144, content=感觉肠道菌群与许多疾病都有一定的相关性, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIJiaCLWwZ60RaAUTVZeItKTcsUicNPFHRB64Bo60Rk8ICbaZCX5YcWrz5kgZqEH8UiaxuECuUufYmZg/132, createdBy=01cb2245548, createdName=呦呦517383645, createdTime=Sat Jan 13 01:35:16 CST 2018, time=2018-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277980, encodeId=907b2e79804a, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIJiaCLWwZ60RaAUTVZeItKTcsUicNPFHRB64Bo60Rk8ICbaZCX5YcWrz5kgZqEH8UiaxuECuUufYmZg/132, createdBy=01cb2245548, createdName=呦呦517383645, createdTime=Sat Jan 13 01:34:48 CST 2018, time=2018-01-13, status=1, ipAttribution=)]
2018-01-14 1249897bm37(暂无昵称)

#肠道菌#

23 0
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17:30:57 CST 2018, time=2018-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277981, encodeId=51ba2e798144, content=感觉肠道菌群与许多疾病都有一定的相关性, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIJiaCLWwZ60RaAUTVZeItKTcsUicNPFHRB64Bo60Rk8ICbaZCX5YcWrz5kgZqEH8UiaxuECuUufYmZg/132, createdBy=01cb2245548, createdName=呦呦517383645, createdTime=Sat Jan 13 01:35:16 CST 2018, time=2018-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277980, encodeId=907b2e79804a, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIJiaCLWwZ60RaAUTVZeItKTcsUicNPFHRB64Bo60Rk8ICbaZCX5YcWrz5kgZqEH8UiaxuECuUufYmZg/132, createdBy=01cb2245548, createdName=呦呦517383645, createdTime=Sat Jan 13 01:34:48 CST 2018, time=2018-01-13, status=1, ipAttribution=)]
2018-01-14 大爰

学习了谢谢分享!!

63 0
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level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jan 17 06:38:08 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353726, encodeId=ff2f1353e26ae, content=<a href='/topic/show?id=dddce266537' target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Jan 14 10:50:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375749, encodeId=134e13e574917, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Sun Jan 14 10:50:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392299, encodeId=1a791392299fd, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Sun Jan 14 10:50:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), 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17:30:57 CST 2018, time=2018-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277981, encodeId=51ba2e798144, content=感觉肠道菌群与许多疾病都有一定的相关性, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIJiaCLWwZ60RaAUTVZeItKTcsUicNPFHRB64Bo60Rk8ICbaZCX5YcWrz5kgZqEH8UiaxuECuUufYmZg/132, createdBy=01cb2245548, createdName=呦呦517383645, createdTime=Sat Jan 13 01:35:16 CST 2018, time=2018-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277980, encodeId=907b2e79804a, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIJiaCLWwZ60RaAUTVZeItKTcsUicNPFHRB64Bo60Rk8ICbaZCX5YcWrz5kgZqEH8UiaxuECuUufYmZg/132, createdBy=01cb2245548, createdName=呦呦517383645, createdTime=Sat Jan 13 01:34:48 CST 2018, time=2018-01-13, status=1, ipAttribution=)]
2018-01-13 wxl882001

学习一下

61 0
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level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jan 17 06:38:08 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353726, encodeId=ff2f1353e26ae, content=<a href='/topic/show?id=dddce266537' target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Jan 14 10:50:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375749, encodeId=134e13e574917, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Sun Jan 14 10:50:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392299, encodeId=1a791392299fd, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Sun Jan 14 10:50:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), 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17:30:57 CST 2018, time=2018-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277981, encodeId=51ba2e798144, content=感觉肠道菌群与许多疾病都有一定的相关性, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIJiaCLWwZ60RaAUTVZeItKTcsUicNPFHRB64Bo60Rk8ICbaZCX5YcWrz5kgZqEH8UiaxuECuUufYmZg/132, createdBy=01cb2245548, createdName=呦呦517383645, createdTime=Sat Jan 13 01:35:16 CST 2018, time=2018-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=277980, encodeId=907b2e79804a, content=谢谢分享学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIJiaCLWwZ60RaAUTVZeItKTcsUicNPFHRB64Bo60Rk8ICbaZCX5YcWrz5kgZqEH8UiaxuECuUufYmZg/132, createdBy=01cb2245548, createdName=呦呦517383645, createdTime=Sat Jan 13 01:34:48 CST 2018, time=2018-01-13, status=1, ipAttribution=)]
2018-01-13 呦呦517383645

感觉肠道菌群与许多疾病都有一定的相关性

21 0
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level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Wed Jan 17 06:38:08 CST 2018, time=2018-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353726, encodeId=ff2f1353e26ae, content=<a href='/topic/show?id=dddce266537' target=_blank style='color:#2F92EE;'>#真菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72665, encryptionId=dddce266537, topicName=真菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Jan 14 10:50:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1375749, encodeId=134e13e574917, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Sun Jan 14 10:50:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1392299, encodeId=1a791392299fd, content=<a href='/topic/show?id=223081e33b6' target=_blank style='color:#2F92EE;'>#肠道菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81733, encryptionId=223081e33b6, topicName=肠道菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aa292500107, createdName=1249897bm37(暂无昵称), createdTime=Sun Jan 14 10:50:00 CST 2018, time=2018-01-14, status=1, ipAttribution=), 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2018-01-13 呦呦517383645

谢谢分享学习了

18 0

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