J Periodontol: 种植体周炎和牙周炎的早期干预

2018-07-21 MedSci MedSci原创

种植体周围炎是组织对细菌生物膜的炎症反应,引起骨吸收,并最终导致种植体脱落。由于缺乏可预测的治疗方法,彻底了解种植体周围炎的发病机制至关重要。本研究的目的是评估和比较急性诱导的种植体周围炎和牙周炎损伤后的反应。

种植体周围炎是组织对细菌生物膜的炎症反应,引起骨吸收,并最终导致种植体脱落。由于缺乏可预测的治疗方法,彻底了解种植体周围炎的发病机制至关重要。本研究的目的是评估和比较急性诱导的种植体周围炎和牙周炎损伤后的反应。

实验采用1个月大的C57BL / 6J雄性小鼠,在拔除其左上颌磨牙后8周,植入种植体。骨整合后,用结扎丝结扎实验组种植体和对侧第二磨牙,对照组不结扎。一周后,一半的结扎线被移除,形成结扎保留和结扎移除两组。在结扎线移除后的两个时间点(第5天和第14天)处死小鼠。通过微型计算机断层扫描和组织学分析标本。

结果:结扎术后第5天和第14天,牙周炎组骨量增加明显,而种植体周围炎组则没有。在组织学上,所有种植体组细胞浸润水平更高。种植体周围炎和牙周炎结扎保留组的破骨细胞数量增加,并且在去除损伤后减少。对于所有组,总体上胶原蛋白在种植体周围炎组中比牙周炎组更加混乱。种植体周围炎实验组的基质金属蛋白酶-8和NF-kB水平比牙周炎组更高。

与牙齿相比,种植体对刺激去除反应较慢且不明显。对于种植体周围炎症病理生理学还需要进一步的深入研究。

原始出处:

Ryan L. W, et al. Early intervention of peri‐implantitis and periodontitis using a mouse model. Journal of Periodontology. 2018 June. doi: 10.1002/JPER.17-0541

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    2018-07-23 feather89
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    2019-06-25 huangdf
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    2018-07-22 飛歌

    学习了很有用

    0

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    2018-07-22 liumin1987

    种植体周炎和牙周炎的早期干预,学习了。

    0

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