BMC Gastroenterology:非酒精性脂肪肝患者维生素D水平低与代谢综合征风险升高有关

2019-10-13 不详 MedSci原创

本项研究旨在评估血清维生素D水平与非酒精性脂肪肝疾病(NAFLD)患者相关疾病之间的关联,例如代谢综合征(MS),炎性细胞因子(肿瘤坏死因子,高敏感性C反应蛋白)和脂肪因子(脂联素,瘦素) 水平等。

背景
本项研究旨在评估血清维生素D水平与非酒精性脂肪肝疾病(NAFLD)患者相关疾病之间的关联,例如代谢综合征(MS),炎性细胞因子(肿瘤坏死因子,高敏感性C反应蛋白)和脂肪因子(脂联素,瘦素) 水平等。

方法
研究人员收集台湾东北地区一家社区医院在2013年8月至2016年8月间所有接受了血液检测和腹部超声检查受试者的临床资料,并进行了了人口统计学调查,维生素D水平通过四分位数划分进行评估,用(<20 ng / ml),(20–30 ng / ml)和(> 30 ng / ml)进行分类。

结果
在进行腹部US研究并匹配年龄和性别后,将受试者分为NAFLD组和正常对照组(每组受试者人数= 564)。NAFLD组平均年龄为57.1岁,对照组为57.5岁。NAFLD组的受试者平均维生素D低于对照组(28.5±9.5 ng / ml VS 29.9±10.2 ng / ml,P= 0.018)。血清维生素D缺乏或不足的受试者的MS机率要高于维生素D水平较高的受试者[P= 0.003]。同样,维生素D最低四分位数的受试者MS的几率高于维生素D最高四分位数的受试者(aOR = 2.792,95%CI = 1.719-4.538,P<0.001)。维生素D水平与年龄和男性呈正相关,但与血清瘦素水平呈负相关。

结论
与高维生素D水平的受试者相比,低维生素D水平的受试者的MS机率更高,但瘦素水平也更高。

原始出处:

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  5. 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  6. [GetPortalCommentsPageByObjectIdResponse(id=2064858, encodeId=299b20648588d, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, createdName=jktdtl, createdTime=Wed Jul 08 22:46:00 CST 2020, time=2020-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1974957, encodeId=3d7b19e49579e, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, 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  7. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1431642, encodeId=963a1431642d3, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Tue Oct 15 13:46:00 CST 2019, time=2019-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504807, encodeId=8fd3150480e52, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, 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    2020-08-31 许安
  8. 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