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Bone Res：Omentin-1通过下调促炎细胞因子来预防炎症诱导的骨质疏松症

2018-04-13 MedSci MedSci原创

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骨质疏松症是慢性炎症性疾病的一种常见并发症，促炎细胞因子的增加促进了骨吸收和损害骨形成加重了骨损失。Omentin-1是一种新发现的具有抗炎作用的脂肪细胞因子，但对omentin-1在炎症性骨质疏松症中的作用知之甚少。本研究中，研究人员构建了omentin-1敲除的（omentin-1 -/-）小鼠，并且证明了omentin-1的敲除在小鼠中诱导炎性骨丢失样表型，增加破骨细胞形成和骨组织破坏，及损

骨质疏松症是慢性炎症性疾病的一种常见并发症，促炎细胞因子的增加促进了骨吸收和损害骨形成加重了骨损失。Omentin-1是一种新发现的具有抗炎作用的脂肪细胞因子，但对omentin-1在炎症性骨质疏松症中的作用知之甚少。

本研究中，研究人员构建了omentin-1敲除的（omentin-1 -/-）小鼠，并且证明了omentin-1的敲除在小鼠中诱导炎性骨丢失样表型，增加破骨细胞形成和骨组织破坏，及损害成骨活性。

使用肿瘤坏死因子-α（TNF-α）诱导的炎性细胞模型，我们确定重组的网膜蛋白-1减少TNF-α激活的巨噬细胞中促炎因子的产生，并抑制其抗成骨细胞和促破骨细胞的能力。在硅酸镁诱导的炎性骨质疏松症小鼠模型中，腺病毒递送的网膜蛋白-1的全身施用可明显防止骨质疏松性骨质流失和炎症的发生。

综上所述，该研究结果表明，omentin-1可通过下调促炎性细胞因子作为预防或治疗炎性骨病的一种有希望的治疗剂。

原始出处：

Shan-Shan Rao, Yin Hu, et al., Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines. Bone Res. 2018; 6: 9.  doi:  10.1038/s41413-018-0012-0

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    2019-01-20 yykkxiaodou

    #促炎细胞因子#

    0

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    2019-01-07 ms6127405442416114

    #促炎#

    0

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    2018-10-07 ms7019579240139182

    #胞因子#

    0

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    2019-02-24 apoenzyme

    #Bone#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1981340, encodeId=60d319813405e, content=<a href='/topic/show?id=5a542e095f8' target=_blank style='color:#2F92EE;'>#促炎细胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27095, encryptionId=5a542e095f8, topicName=促炎细胞因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3883266, createdName=yykkxiaodou, createdTime=Sun Jan 20 09:32:00 CST 2019, time=2019-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1690045, encodeId=a1fc169004562, content=<a href='/topic/show?id=fb802e08724' target=_blank style='color:#2F92EE;'>#促炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27087, encryptionId=fb802e08724, topicName=促炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b3128951451, createdName=ms6127405442416114, createdTime=Mon Jan 07 02:32:00 CST 2019, time=2019-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809560, encodeId=89b718095605f, content=<a href='/topic/show?id=6cd683e603b' target=_blank style='color:#2F92EE;'>#胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83760, encryptionId=6cd683e603b, topicName=胞因子)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/017ED6AFEB45F49165298113DDC0656A/100, createdBy=84182500174, createdName=ms7019579240139182, createdTime=Sun Oct 07 11:32:00 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1915175, encodeId=bc1c19151e53a, content=<a href='/topic/show?id=05343619cf' target=_blank style='color:#2F92EE;'>#Bone#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3619, encryptionId=05343619cf, topicName=Bone)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, createdName=apoenzyme, createdTime=Sun Feb 24 17:32:00 CST 2019, time=2019-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1283594, encodeId=af7f128359401, content=<a href='/topic/show?id=2c00e784416' target=_blank style='color:#2F92EE;'>#细胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77844, encryptionId=2c00e784416, topicName=细胞因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sun Apr 15 07:32:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592447, encodeId=b004159244e6c, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Sun Apr 15 07:32:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305437, encodeId=2eb130543e78, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Fri Apr 13 17:44:39 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305426, encodeId=924d305426c0, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Fri Apr 13 16:44:24 CST 2018, time=2018-04-13, status=1, ipAttribution=)]
    2018-04-15 智智灵药

    #细胞因子#

    0

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    2018-04-15 Eleven17

    #骨质#

    0

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    2018-04-13 changjiu

    学习一下谢谢

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1981340, encodeId=60d319813405e, content=<a href='/topic/show?id=5a542e095f8' target=_blank style='color:#2F92EE;'>#促炎细胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27095, encryptionId=5a542e095f8, topicName=促炎细胞因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3883266, createdName=yykkxiaodou, createdTime=Sun Jan 20 09:32:00 CST 2019, time=2019-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1690045, encodeId=a1fc169004562, content=<a href='/topic/show?id=fb802e08724' target=_blank style='color:#2F92EE;'>#促炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27087, encryptionId=fb802e08724, topicName=促炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1b3128951451, createdName=ms6127405442416114, createdTime=Mon Jan 07 02:32:00 CST 2019, time=2019-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1809560, encodeId=89b718095605f, content=<a href='/topic/show?id=6cd683e603b' target=_blank style='color:#2F92EE;'>#胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83760, encryptionId=6cd683e603b, topicName=胞因子)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/101296147/017ED6AFEB45F49165298113DDC0656A/100, createdBy=84182500174, createdName=ms7019579240139182, createdTime=Sun Oct 07 11:32:00 CST 2018, time=2018-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1915175, encodeId=bc1c19151e53a, content=<a href='/topic/show?id=05343619cf' target=_blank style='color:#2F92EE;'>#Bone#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3619, encryptionId=05343619cf, topicName=Bone)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7dc7399, createdName=apoenzyme, createdTime=Sun Feb 24 17:32:00 CST 2019, time=2019-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1283594, encodeId=af7f128359401, content=<a href='/topic/show?id=2c00e784416' target=_blank style='color:#2F92EE;'>#细胞因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77844, encryptionId=2c00e784416, topicName=细胞因子)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Sun Apr 15 07:32:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592447, encodeId=b004159244e6c, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Sun Apr 15 07:32:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305437, encodeId=2eb130543e78, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Fri Apr 13 17:44:39 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305426, encodeId=924d305426c0, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Fri Apr 13 16:44:24 CST 2018, time=2018-04-13, status=1, ipAttribution=)]
    2018-04-13 九九消寒

    优质资源.共同学习

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