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Int J Cardiol：妊娠前期接触他汀类药物与胎儿室间隔缺损相关

2018-07-07 xing.T MedSci原创

妊娠前期他汀类药物室间隔缺损
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由此可见，在妊娠前期接触他汀类药物与胎儿室间隔缺损有关。

越来越多的年轻女性在妊娠前期接触他汀类药物。近日，心血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章，该研究的目的是评估妊娠早期接触他汀类药物是否与胎儿先天性心脏异常风险增加有关。

在379238例孕妇的队列中，研究人员使用logistic回归模型和倾向评分匹配方法评估了妊娠前期接触他汀类药物治疗与胎儿发生先天性心脏异常的风险之间的关系。

280名妇女接触他汀类药物。14例（5.0％）接触他汀类药物的孕妇和5282例（1.4％）未接触他汀类药物的孕妇生出的胎儿出现先天性心脏异常。妊娠早期接触他汀类药物与室间隔缺损风险增加相关（校正后比值比[OR]为3.3,95％可信区间[CI]为1.8-6.0，p<0.001）。研究人员使用倾向评分匹配的队列（OR为4.7,95％CI为2.0-10.8，p<0.001）分析证实了这种关联。

由此可见，在妊娠前期接触他汀类药物与胎儿室间隔缺损有关。

原始出处：

Ming-SumLee,et al. Statin exposure during first trimester of pregnancy is associated with fetal ventricular septal defect.International Journal of Cardiology.2018. https://doi.org/10.1016/j.ijcard.2018.07.002

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    2018-10-31 minhuang75_72521584

    #室间隔#

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    2018-07-22 医者仁心

    #他汀类药#

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    2019-01-23 仁者大医

    #Cardiol#

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    2019-05-01 1249898am15暂无昵称

    #妊娠前#

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    2018-07-18 jyzxjiangqin

    妊娠前期接触他汀

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1924281, encodeId=5bbb1924281f6, content=<a href='/topic/show?id=a1444624457' target=_blank style='color:#2F92EE;'>#室间隔#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46244, encryptionId=a1444624457, topicName=室间隔)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=05202500204, createdName=minhuang75_72521584, createdTime=Wed Oct 31 03:10:00 CST 2018, time=2018-10-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2044510, encodeId=62382044510ee, content=<a href='/topic/show?id=644725344b1' target=_blank style='color:#2F92EE;'>#他汀类药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25344, encryptionId=644725344b1, topicName=他汀类药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Sun Jul 22 23:10:00 CST 2018, time=2018-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1781922, encodeId=3dff1e8192202, content=<a href='/topic/show?id=5db8409ed8' target=_blank style='color:#2F92EE;'>#Cardiol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4097, encryptionId=5db8409ed8, topicName=Cardiol)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Wed Jan 23 06:10:00 CST 2019, time=2019-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1946746, encodeId=362a1946e4654, content=<a href='/topic/show?id=8a0844838ca' target=_blank style='color:#2F92EE;'>#妊娠前#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44838, encryptionId=8a0844838ca, topicName=妊娠前)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=38232500109, createdName=1249898am15暂无昵称, createdTime=Wed May 01 05:10:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=332465, encodeId=b7a333246577, content=妊娠前期接触他汀, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Wed Jul 18 12:08:40 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=330013, encodeId=312c3300133d, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2ac82155377, createdName=1201e5c5m39暂无昵称, createdTime=Sat Jul 07 15:11:12 CST 2018, time=2018-07-07, status=1, ipAttribution=)]
    2018-07-07 1201e5c5m39暂无昵称

    学习了

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