Neurology:脑动静脉畸形患者的长期健康相关生活质量

2019-09-12 xing.T MedSci原创

通过仔细选择患者,SPC B类患者可获得与SPC A类患者相同的HRQOL,提前是手术成功。应采取有效治疗以防止完全AVM闭塞,预防多次出血事件。AVM患者的术后治疗应侧重于预防抑郁症状、焦虑和癫痫发作。研究人员鼓励其他研究小组使用HRQOL工具充分了解神经病学和神经外科疾病对患者HRQOL的影响。

近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员为了明确经治疗的动静脉畸形(AVM)患者健康相关生活质量(HRQOL),研究人员使用自我使用的HRQOL工具-15D分析了整个研究人群和指定队列的得分。

研究人员将15D问卷邮寄给数据库中2016年仍存活的AVM成年患者(n=432),完全根治的AVM的患者(n=262)被纳入随后的分析中。将结果与标准化年龄和性别的一般人群进行比较,研究人员使用独立样本t检验或协方差分析,对癫痫、出血发作次数、病变部位、改良Rankin量表评分和Spetzler-Ponce分类(SPC)进行亚组分析。Tobit回归用于解释15D评分的变化。

与参考人群相比,患者HRQOL受损(p<0.0001)。位置较深、多次出血事件和难治性癫痫与HRQOL受损有关。SPC A和B患者的治疗后15D评分相似,而C类患者的HRQOL评分则受损。回归模型中显著的解释变量包括年龄、性别、出血次数、难治性癫痫和SPC。

由此可见,通过仔细选择患者,SPC B类患者可获得与SPC A类患者相同的HRQOL,提前是手术成功。应采取有效治疗以防止完全AVM闭塞,预防多次出血事件。AVM患者的术后治疗应侧重于预防抑郁症状、焦虑和癫痫发作。研究人员鼓励其他研究小组使用HRQOL工具充分了解神经病学和神经外科疾病对患者HRQOL的影响。 

原始出处:

Anni Pohjola,et al.Long-term health-related quality of life in 262 patients with brain arteriovenous malformation.Neurology.2019.https://n.neurology.org/content/early/2019/09/11/WNL.0000000000008196

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    2020-02-28 fusion
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    2020-03-10 yinhl1978
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    2019-09-13 wushaoling
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