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BMJ Open Diabetes Res Care：血清维生素D不足和牙周炎对胰岛素抵抗，糖尿病前期和2型糖尿病的作用

2018-08-05 MedSci MedSci原创

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牙周炎与糖尿病密切相关，并且越来越多地显示与其他血糖异常有关。假定维生素D具有抗炎和抗微生物活性。因此，本研究旨在评估血清25-羟基维生素D3和总25-羟基维生素D与牙周炎的联合作用对胰岛素抵抗（HOMA-IR），糖尿病前期和2型糖尿病的作用。根据2009-2010国家健康和营养检查调查的数据，该样本仅限于30岁以上的成年人，进行口腔健康检查，并测量维生素D，空腹血糖和胰岛素。分析样本包括具有（n

牙周炎与糖尿病密切相关，并且越来越多地显示与其他血糖异常有关。假定维生素D具有抗炎和抗微生物活性。因此，本研究旨在评估血清25-羟基维生素D3和总25-羟基维生素D与牙周炎的联合作用对胰岛素抵抗（HOMA-IR），糖尿病前期和2型糖尿病的作用。

根据2009-2010国家健康和营养检查调查的数据，该样本仅限于30岁以上的成年人，进行口腔健康检查，并测量维生素D，空腹血糖和胰岛素。分析样本包括具有（n = 1631）和无（n = 1369）2型糖尿病的那些人。使用调查逻辑多变量回归分析，我们检查了以下联合效应：（1）维生素D不足（<50 nmol / L）和中度至重度牙周炎（VD + PD +）; （2）维生素D不足，轻度至无牙周炎（VD + PD-）; （3）维生素D充足性（> 50 nmol / L）和牙周炎（VD-PD +），并将这些组与双重未暴露的参考组（VD-PD-）进行比较。

结果显示，维生素D3不足和总维生素D不足与牙周炎（VD + PD +）的联合作用与糖尿病显著相关：OR = 2.83（95％CI 1.34-5.96）和OR = 1.98（95％CI 1.04-3.76）。然而，维生素D3不足和牙周炎的联合作用对于HOMA-IR 4.17较弱：OR = 1.57（95％CI 0.97-2.55）。前驱糖尿病与任何一种联合效应无关。

表明在这个具有全国代表性的横断面样本中，维生素D和牙周炎的联合作用似乎与HOMA-IR，糖尿病前期和糖尿病不同。

原始出处：

Zuk AM, Quiñonez CR, et al., Joint effects of serum vitamin D insufficiency and periodontitis on insulin resistance, pre-diabetes, and type 2 diabetes: results from the National Health and Nutrition Examination Survey (NHANES) 2009-2010. BMJ Open Diabetes Res Care. 2018 Jul 23;6(1):e000535. doi: 10.1136/bmjdrc-2018-000535. eCollection 2018.

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    2018-08-28 木头人513

    #Diabetes#

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    2019-05-17 ms5439512287675881

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    2018-12-14 ms9608593228839890

    #DIA#

    0

  4. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336744, encodeId=3814336e4439, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Aug 06 06:17:30 CST 2018, time=2018-08-06, status=1, ipAttribution=)]
    2018-12-21 gaoxiaoe

    #BMJ#

    0

  5. 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content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Aug 06 07:51:42 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336765, encodeId=0261336e654e, content=学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Mon Aug 06 07:03:04 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336744, encodeId=3814336e4439, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Aug 06 06:17:30 CST 2018, time=2018-08-06, status=1, ipAttribution=)]
    2019-01-20 feather89

    #PE#

    0

  6. 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content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Aug 06 07:51:42 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336765, encodeId=0261336e654e, content=学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Mon Aug 06 07:03:04 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336744, encodeId=3814336e4439, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Aug 06 06:17:30 CST 2018, time=2018-08-06, status=1, ipAttribution=)]
    2018-10-10 baoya

    #胰岛#

    0

  7. 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content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Aug 06 07:51:42 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336765, encodeId=0261336e654e, content=学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Mon Aug 06 07:03:04 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336744, encodeId=3814336e4439, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Aug 06 06:17:30 CST 2018, time=2018-08-06, status=1, ipAttribution=)]
    2018-08-07 liuyong2982

    #牙周#

    0

  8. 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content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Aug 06 07:51:42 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336765, encodeId=0261336e654e, content=学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Mon Aug 06 07:03:04 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336744, encodeId=3814336e4439, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Aug 06 06:17:30 CST 2018, time=2018-08-06, status=1, ipAttribution=)]
    2018-08-06 龙胆草

    学习谢谢分享

    0

  9. 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content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Aug 06 07:51:42 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336765, encodeId=0261336e654e, content=学习学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Mon Aug 06 07:03:04 CST 2018, time=2018-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336744, encodeId=3814336e4439, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Aug 06 06:17:30 CST 2018, time=2018-08-06, status=1, ipAttribution=)]
    2018-08-06 jihuaijun1112

    学习学习学习学习

    0

  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=336744, encodeId=3814336e4439, content=谢谢分享，学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Mon Aug 06 06:17:30 CST 2018, time=2018-08-06, status=1, ipAttribution=)]
    2018-08-06 明月清辉

    谢谢分享，学习了

    0

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