J Hypertens:甲状腺功能正常个体甲状腺刺激素与高血压风险之间的剂量-反应关系

2018-07-07 xing.T MedSci原创

由此可见,当前的研究为甲状腺功能正常的个体血清TSH水平与高血压风险之间的剂量-反应关系提供了有力的证据。TSH水平较高的正常甲状腺功能正常个体发生高血压的风险高于正常TSH水平的个体。

甲状腺功能紊乱对心血管系统的不良影响尚未确定,但甲状腺功能亢进症患者甲状腺刺激素(TSH)水平与高血压风险之间的关系尚无定论。

近日,高血压领域权威杂志Journal of Hypertension上发表了一篇研究文章,研究人员进行了一项基于人群的横断面研究,以评估甲状腺功能亢进症患者TSH水平与高血压风险之间的关系,并进行logistic回归分析。此外,研究人员进行了相关队列或横断面研究的剂量反应荟萃分析,以进一步评估TSH对甲状腺功能亢进个体的高血压风险的影响。

在该横断面研究中,研究人员共招募了2289名无甲状腺疾病的正常人。正常参考范围上限的血清TSH水平与高血压风险较高[比值比(OR)=1.29,95%置信区间(CI)为1.04-1.61,P=0.023]相关。在调整混杂因素后,高血压OR仍有统计学意义(OR=1.32,95%CI为1.01-1.72,P=0.041)。此外,荟萃分析表明甲状腺功能正常患者TSH水平与高血压风险之间存在明显的剂量-反应关系,TSH水平每升高1mIU/l对应的发生高血压OR值为1.09(95%CI为1.04-1.14,P <0.001)。Meta分析还显示TSH水平每升高1mIU/l与SBP和DBP相关的β系数分别为0.78(95%CI为0.37-1.18,P<0.001)和0.45(95%CI为0.15-0.76,P=0.004)。

由此可见,当前的研究为甲状腺功能正常的个体血清TSH水平与高血压风险之间的剂量-反应关系提供了有力的证据。TSH水平较高的正常甲状腺功能正常个体发生高血压的风险高于正常TSH水平的个体。

原始出处:

He, Weiwei.et al. Dose–response relationship between thyroid stimulating hormone and hypertension risk in euthyroid individuals.Journal of Hypertension. 2018. https://journals.lww.com/jhypertension/Abstract/publishahead/Dose_response_relationship_between_thyroid.97421.aspx

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    2019-06-18 feather89
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    2018-07-18 jyzxjiangqin

    甲状腺功能的检查

    0

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    2018-07-10 惠映实验室

    学习了.谢谢分享.

    0

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    2018-07-08 186****0580(小山羊)

    学习了谢谢了

    0

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    2018-07-07 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

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    2018-07-07 虈亣靌

    学习学习学习

    0