GUT: 急慢性肝衰竭的细菌和真菌感染对于患病率,患病特征和对预后的影响

2018-09-23 MedSci MedSci原创

细菌感染是急性慢性肝功能衰竭(ACLF)的常见诱因。本项研究评估了导致ACLF发生的细菌和真菌感染的特征,以及细菌感染的预测因子和细菌感染对生存的影响。

抽象:
细菌感染是急性慢性肝功能衰竭(ACLF)的常见诱因。本项研究评估了导致ACLF发生的细菌和真菌感染的特征,以及细菌感染的预测因子和细菌感染对生存的影响。

方法:
本项研究共纳入407例ACLF患者和235例急性失代偿(AD)患者。在ACLF患者中,152名患者(37%)出现细菌感染;其余255例ACLF患者中46%(n = 117)在随访期间(4周)发生细菌感染。AD患者的相应数字分别为25%和18%(p <0.001)。在ACLF患者中,严重感染(自发性细菌性腹膜炎,肺炎,严重脓毒症/休克,医院感染和多重耐药性引起的感染)更为普遍。ACLF和细菌感染患者与没有感染的ACLF患者相比,90天的生存率(49%vs 72.5%; p <0.001)更低。

结论:
ACLF中细菌感染极为常见。它们与强烈的全身性炎症,不良的临床过程和高死亡率相关。

原始出处:

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    2018-09-25 zhaojie88
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