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J Endod：鼻内3%丁卡因加0.05%羟甲唑啉(Kovanaze)对上颌磨牙的麻醉效果

2019-03-18 lishiting MedSci原创

麻醉方式羟甲唑啉鼻内喷雾
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非注射式麻醉是常规麻醉给药途径的一种有希望的替代产品。这篇研究的目的是为了评估患者的优先选择性以及3%丁卡因加0.05%羟甲唑啉(Kovanaze)鼻内喷雾麻醉对上颌侧切牙和第一前磨牙的麻醉效果。

非注射式麻醉是常规麻醉给药途径的一种有希望的替代产品。这篇研究的目的是为了评估患者的优先选择性以及3%丁卡因加0.05%羟甲唑啉(Kovanaze)鼻内喷雾麻醉对上颌侧切牙和第一前磨牙的麻醉效果。研究按照单盲交叉设计对50名成年患者在2个特定的位置相隔至少1周随机施以3%丁卡因加0.05%羟甲唑啉(Kovanaze) 鼻内喷雾和模拟浸润麻醉或者模拟鼻内喷雾和2%利多卡因加1：100，000肾上腺素以麻醉上颌侧切牙和第一前磨牙。通过电活力测试检验牙髓麻醉效果。记录副作用和受试者表现。结果显示，Kovanaze鼻内喷雾和模拟浸润麻醉(22%-37%)的麻醉成功率要明显低于模拟鼻内喷雾和利多卡因浸润麻醉(89%-91%)。受试者的记录显示，Kovanaze鼻内喷雾和模拟浸润麻醉后比模拟鼻内喷雾和利多卡因浸润麻醉产生更多不适感（鼻内流涕和充血、灼烧、压力和鼻窦充血）。在加入调查研究前，更多的受试者倾向于选择鼻内喷雾的途径(56%)而非标准的浸润麻醉(44%)。经历2种给药途径后，100%受试者优先选择标准的浸润麻醉。结论：3%丁卡因加0.05%羟甲唑啉(Kovanaze) 鼻内喷雾的麻醉效果明

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    2019-09-15 12498e5fm22(暂无昵称)

    #AZ#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1714825, encodeId=95701e1482518, content=<a href='/topic/show?id=021230e312' target=_blank style='color:#2F92EE;'>#AZ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3073, encryptionId=021230e312, topicName=AZ)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9e5031899089, createdName=12498e5fm22(暂无昵称), createdTime=Sun Sep 15 03:57:00 CST 2019, time=2019-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2079962, encodeId=085620e9962df, content=<a href='/topic/show?id=929880015d6' target=_blank style='color:#2F92EE;'>#羟甲唑啉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80015, encryptionId=929880015d6, topicName=羟甲唑啉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85aa264, createdName=redcrab, createdTime=Wed Jul 31 06:57:00 CST 2019, time=2019-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1633512, encodeId=c194163351247, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Wed Nov 13 01:57:00 CST 2019, time=2019-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=363714, encodeId=9237363e1498, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220814/be36b1918b4c4eeba48ae6c167571ce9/3bd4e17f256d4fdba54abc66bb0f616c.jpg, createdBy=a4042044999, createdName=jiangwei200908, createdTime=Thu Mar 28 21:41:39 CST 2019, time=2019-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576200, encodeId=1b8115e620011, content=<a href='/topic/show?id=05a7e3816d7' target=_blank style='color:#2F92EE;'>#磨牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73816, encryptionId=05a7e3816d7, topicName=磨牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=570716304996, createdName=12498474m35暂无昵称, createdTime=Wed Mar 20 11:57:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631167, encodeId=c31a163116edd, content=<a href='/topic/show?id=271b20090b0' target=_blank style='color:#2F92EE;'>#上颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20090, encryptionId=271b20090b0, topicName=上颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c07f21689347, createdName=hanhaisha2015, createdTime=Wed Mar 20 11:57:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046776, encodeId=894b1046e7629, content=疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Mon Mar 18 23:57:00 CST 2019, time=2019-03-18, status=1, ipAttribution=)]
    2019-07-31 redcrab

    #羟甲唑啉#

    0

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    2019-11-13 AspirantSuo

    #ANA#

    0

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    2019-03-28 jiangwei200908

    不错不错

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1714825, encodeId=95701e1482518, content=<a href='/topic/show?id=021230e312' target=_blank style='color:#2F92EE;'>#AZ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3073, encryptionId=021230e312, topicName=AZ)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9e5031899089, createdName=12498e5fm22(暂无昵称), createdTime=Sun Sep 15 03:57:00 CST 2019, time=2019-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2079962, encodeId=085620e9962df, content=<a href='/topic/show?id=929880015d6' target=_blank style='color:#2F92EE;'>#羟甲唑啉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80015, encryptionId=929880015d6, topicName=羟甲唑啉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85aa264, createdName=redcrab, createdTime=Wed Jul 31 06:57:00 CST 2019, time=2019-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1633512, encodeId=c194163351247, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Wed Nov 13 01:57:00 CST 2019, time=2019-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=363714, encodeId=9237363e1498, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220814/be36b1918b4c4eeba48ae6c167571ce9/3bd4e17f256d4fdba54abc66bb0f616c.jpg, createdBy=a4042044999, createdName=jiangwei200908, createdTime=Thu Mar 28 21:41:39 CST 2019, time=2019-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576200, encodeId=1b8115e620011, content=<a href='/topic/show?id=05a7e3816d7' target=_blank style='color:#2F92EE;'>#磨牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73816, encryptionId=05a7e3816d7, topicName=磨牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=570716304996, createdName=12498474m35暂无昵称, createdTime=Wed Mar 20 11:57:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631167, encodeId=c31a163116edd, content=<a href='/topic/show?id=271b20090b0' target=_blank style='color:#2F92EE;'>#上颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20090, encryptionId=271b20090b0, topicName=上颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c07f21689347, createdName=hanhaisha2015, createdTime=Wed Mar 20 11:57:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046776, encodeId=894b1046e7629, content=疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Mon Mar 18 23:57:00 CST 2019, time=2019-03-18, status=1, ipAttribution=)]
    2019-03-20 12498474m35暂无昵称

    #磨牙#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1714825, encodeId=95701e1482518, content=<a href='/topic/show?id=021230e312' target=_blank style='color:#2F92EE;'>#AZ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3073, encryptionId=021230e312, topicName=AZ)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9e5031899089, createdName=12498e5fm22(暂无昵称), createdTime=Sun Sep 15 03:57:00 CST 2019, time=2019-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2079962, encodeId=085620e9962df, content=<a href='/topic/show?id=929880015d6' target=_blank style='color:#2F92EE;'>#羟甲唑啉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80015, encryptionId=929880015d6, topicName=羟甲唑啉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85aa264, createdName=redcrab, createdTime=Wed Jul 31 06:57:00 CST 2019, time=2019-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1633512, encodeId=c194163351247, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Wed Nov 13 01:57:00 CST 2019, time=2019-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=363714, encodeId=9237363e1498, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220814/be36b1918b4c4eeba48ae6c167571ce9/3bd4e17f256d4fdba54abc66bb0f616c.jpg, createdBy=a4042044999, createdName=jiangwei200908, createdTime=Thu Mar 28 21:41:39 CST 2019, time=2019-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576200, encodeId=1b8115e620011, content=<a href='/topic/show?id=05a7e3816d7' target=_blank style='color:#2F92EE;'>#磨牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73816, encryptionId=05a7e3816d7, topicName=磨牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=570716304996, createdName=12498474m35暂无昵称, createdTime=Wed Mar 20 11:57:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631167, encodeId=c31a163116edd, content=<a href='/topic/show?id=271b20090b0' target=_blank style='color:#2F92EE;'>#上颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20090, encryptionId=271b20090b0, topicName=上颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c07f21689347, createdName=hanhaisha2015, createdTime=Wed Mar 20 11:57:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046776, encodeId=894b1046e7629, content=疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Mon Mar 18 23:57:00 CST 2019, time=2019-03-18, status=1, ipAttribution=)]
    2019-03-20 hanhaisha2015

    #上颌#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1714825, encodeId=95701e1482518, content=<a href='/topic/show?id=021230e312' target=_blank style='color:#2F92EE;'>#AZ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3073, encryptionId=021230e312, topicName=AZ)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9e5031899089, createdName=12498e5fm22(暂无昵称), createdTime=Sun Sep 15 03:57:00 CST 2019, time=2019-09-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2079962, encodeId=085620e9962df, content=<a href='/topic/show?id=929880015d6' target=_blank style='color:#2F92EE;'>#羟甲唑啉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80015, encryptionId=929880015d6, topicName=羟甲唑啉)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=85aa264, createdName=redcrab, createdTime=Wed Jul 31 06:57:00 CST 2019, time=2019-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1633512, encodeId=c194163351247, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Wed Nov 13 01:57:00 CST 2019, time=2019-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=363714, encodeId=9237363e1498, content=不错不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220814/be36b1918b4c4eeba48ae6c167571ce9/3bd4e17f256d4fdba54abc66bb0f616c.jpg, createdBy=a4042044999, createdName=jiangwei200908, createdTime=Thu Mar 28 21:41:39 CST 2019, time=2019-03-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1576200, encodeId=1b8115e620011, content=<a href='/topic/show?id=05a7e3816d7' target=_blank style='color:#2F92EE;'>#磨牙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73816, encryptionId=05a7e3816d7, topicName=磨牙)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=570716304996, createdName=12498474m35暂无昵称, createdTime=Wed Mar 20 11:57:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1631167, encodeId=c31a163116edd, content=<a href='/topic/show?id=271b20090b0' target=_blank style='color:#2F92EE;'>#上颌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=20090, encryptionId=271b20090b0, topicName=上颌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c07f21689347, createdName=hanhaisha2015, createdTime=Wed Mar 20 11:57:00 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1046776, encodeId=894b1046e7629, content=疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Mon Mar 18 23:57:00 CST 2019, time=2019-03-18, status=1, ipAttribution=)]
    2019-03-18 CHANGE

    疗效只是效果的众多方面之一，还要看对患者的获益，包括生活质量等因素共同决定效果的

    0