Clin Trans Gastro: 粪菌移植对肠易激综合征患者症状,内脏感知及粪便和粘膜微生物的影响

2019-05-20 不详 MedSci原创

粪便微生物群转移(FMT)被认为是肠易激综合征(IBS)患者的潜在治疗方法。本项研究的目的是研究同种异体和自体FMT对IBS症状,内脏敏感性和组粪便和粘膜粘附微生物群成变化的影响。

背景及目标:
粪便微生物群转移(FMT)被认为是肠易激综合征(IBS)患者的潜在治疗方法。本项研究的目的是研究同种异体和自体FMT对IBS症状,内脏敏感性和组粪便和粘膜粘附微生物群成变化的影响。

方法:
17名IBS患者被随机分配接受健康供体(同种异体)的粪便物质或接受自己的粪便物质(自体)。在肠清洁后通过全结肠镜检查将粪便物质放置到盲肠中。

结果:
同种异体和自体FMT在症状评分方面没有显着差异。然而,与基线相比,接受同种异体粪便物质的患者的症状评分显着降低(P = 0.02),而自体组则不然(P = 0.16)。内脏敏感性没有受到影响。虽然一些患者的粪便和粘膜粘附微生物群转移到它们各自的供体粪便微生物群,但一些患者在同种异体FMT后没有显示相关的微生物变化。

结论:
本研究表明,单次FMT结肠镜检查可能对IBS有益; 然而,同种异体粪便物质并不优于自体粪便物质。

原始出处:

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    2020-03-27 guoyibin
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    2019-09-05 许安
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    2019-12-31 bsmagic9140
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    2019-05-22 Homburg

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随机双盲安慰剂对照研究证实,肠易激综合征患者接受粪便微生物移植对患者临床症状及菌群多样性有积极影响

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近期,医脉通整理了发表在Alimentary Pharmacology and Therapeutics杂志上的关于粪便微生物群移植(FMT)的共识报告。上一篇文章中着重介绍了FMT的临床指征,本文对FMT临床实验设计,捐赠者选择,粪便准备以及接受FMT患者(以下称受体)准备的重要推荐进行介绍,详情如下:当应用FMT计划临床研究时,需要考虑的重点包括以下:捐赠者选择的重要推荐在捐赠者选择上,可能导

Ann Intern Med:粪便菌群移植的现状分析!

由此可见,FMT干预的关键组分,其对于重复和理解研究结果的有效性和安全性是很有必要的,并未被充分进行报道。

SCI REP:多次新鲜粪便微生物移植诱导并维持Crohn病并发炎症性肿块的临床缓解!

这种务实的研究表明序贯新鲜的FMTs可能是一种有效、安全的治疗方法来诱导和维持有腹腔内炎性包块的CD患者的临床缓解。