Nature:科学家发现噬菌体在金黄色葡萄球菌的增殖和感染过程中的关键作用

2018-12-07 佚名 科技部

近日,德国蒂宾根大学等科学家在Nature杂志上发表了题为“Methicillin-resistant Staphylococcus aureus alters cell wall glycosylation to evade immunity”的文章,探讨了噬菌体在维持金黄色葡萄球菌的增殖和感染过程中的关键作用。

近日,德国蒂宾根大学等科学家在Nature杂志上发表了题为“Methicillin-resistant Staphylococcus aureus alters cell wall glycosylation to evade immunity”的文章,探讨了噬菌体在维持金黄色葡萄球菌的增殖和感染过程中的关键作用。

金黄色葡萄球菌是最为棘手的导致人类感染的原因之一。尽管通常情况下,生活在鼻腔、呼吸道和生殖组织中的金黄色葡萄球菌不会引发疾病,但是,与许多其他常居菌(resident bacteria)不同,金黄色葡萄球菌具有引起潜在致命感染的能力。这种细菌似乎可以根据宿主的身体状况改变“入侵”策略,如在探测到宿主发生疾病引起的免疫防御能力下降时,细菌的种群就可以扩大到能够导致宿主死亡的水平。大部分人体产生的抗体通过识别金黄色葡萄球菌细胞壁中壁磷壁酸(wall teichoic acid, WTA)发挥作用,科研人员发现一种来源于病毒的基因编码的蛋白酶可以通过改变WTA的结构以降低触发宿主的免疫应答。

在过去的50年中,金黄色葡萄球菌对抗生素的耐药性已成为一个日益严重的问题。本研究一方面增进了人们对于人体与微生物之间相互作用关系的认识,即宿主与常居微生物之间微妙的平衡关系可能受到利益相关的第三方的影响;另一方面,在一些人所谓的“后抗生素时代”来临之际,鉴于耐药细菌的数量的增加以及可应用于临床的新抗生素研发的局限性,本研究对新的感染控制管理策略的开发具有一定借鉴意义。

原始出处:Gerlach D, Guo Y, De Castro C, et al. Methicillin-resistant Staphylococcus aureus alters cell wall glycosylation to evade immunity. Nature. 2018 Nov;563(7733):705-709. 

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    2019-06-07 liye789132251
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    2018-12-12 kafei

    学习了谢谢

    0

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