JAMA Oncol:中国肝癌标化死亡率下降1/3

2017-10-13 凤凤 医师报

近日,《JAMA Oncol》杂志发表的2015年全球疾病负担研究(GBD)发现,1990-2015年间,东亚及西撒哈拉以南非洲地区则大幅下降,我国肝癌年龄标准化死亡率下降了1/3。(JAMA Oncol.10月5日在线版)


近日,《JAMA Oncol》杂志发表的2015年全球疾病负担研究(GBD)发现,1990-2015年间,东亚及西撒哈拉以南非洲地区则大幅下降,我国肝癌年龄标准化死亡率下降了1/3。(JAMA Oncol.10月5日在线版)

 
“肝癌是位于肺、大肠、胃癌之后的癌症死亡第4大原因”,研究者表示,至2015年,全球共新发肝癌85.4 万例,81万例死亡。共导致伤残调整寿命年(DALYs)2057.8 万例。研究指出,1990-2015年间,全球肝癌病例增加75%,其中影响最大的病因是丙肝(HCV),其次是酒精。针对亚太地区高收入国家的分析显示,日本新发肝癌病例中,2/3由HCV感染引起。肝癌的年龄标准化发病率也表明,在包括美国、加拿大、澳大利亚、新西兰和大多数欧洲国家的高收入地区,肝癌年龄标准化死亡率增加了100%以上。另一方面,东亚及西撒哈拉以南非洲地区则大幅下降(图1)。如我国1990-2015年间肝癌年龄标准化死亡率下降了1/3,这可能是由于在一定程度上减少了黄曲霉毒素暴露,及施行全国乙肝(HBV)疫苗接种计划。

另外,该研究对肝癌病因的分析中,14%的研究报告了性别为潜在影响因素。结果显示,肝癌在男性中更常见,为59.1 万例,女性26.4 万例,死亡率为男性57.7万例,女性23.4万例,DALYs为男性1541.3万例,女性516.5万例。2015年,全球由乙肝造成的肝癌男性20.3 例(95%UI,17.1万~25.1万),女性仅7万例(95%UI,5.7万~8.6 万)。酒精造成男性肝癌20.4万例(95%UI,17.7万~24万),女性4.5 万例(95%UI,3.8万~5.4万)。

以上研究结果表明,在过去的25年里,世界上大部分地区肝癌的发病率有所上升,但这种癌症的发病原因因地域而异,而且在一定程度上也因收入而异,但大多数肝癌可通过疫苗接种、抗病毒治疗、安全输血和注射治疗以及减少酗酒等措施预防。根据可持续发展目标,确定和消除肝癌危险因素有助于持续减轻肝癌负担。GBD研究可以引导这些预防措施。

原始出处:

Global Burden of Disease Liver Cancer Collaboration.The Burden of Primary Liver Cancer and Underlying Etiologies From 1990 to 2015 at the Global, Regional, and National Level: Results From the Global Burden of Disease Study 2015.JAMA Oncol. Published online October 5, 2017. doi:10.1001/jamaoncol.2017.3055

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1865146, encodeId=b16c18651469b, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri Jul 20 04:41:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255141, encodeId=5074255141a3, content=不错的.学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Oct 22 19:12:40 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254283, encodeId=75a0254283e8, content=非常好.学习了.很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Oct 19 11:36:34 CST 2017, time=2017-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253346, encodeId=157125334661, content=很好很好很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/07/8c1e5a0085f3b74f3a4ab58a38a3d487.jpg, createdBy=b33e2159612, createdName=2227437833_79976374, createdTime=Mon Oct 16 08:16:30 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253178, encodeId=0dfd2531e8f7, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/01/a422505c84c5bd7df245dee314debefc.jpg, createdBy=31332101574, createdName=kalery, createdTime=Sun Oct 15 18:19:19 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253002, encodeId=f65b25300264, content=好的.谢谢分享下.mark, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/mzZkwf53jx0oribz8WkmVTPTSib4iaRMXz6nkEOaqWPjgyYWQoLa8J2WCicWvb8SrhhZz5sgUcwmQnMQ1lJcA7Fhxg/0, createdBy=9b182084756, createdName=yunger, createdTime=Sun Oct 15 06:51:59 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252633, encodeId=4738252633e4, content=肝癌死亡率下降.得利于乙肝预防., beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri Oct 13 20:49:07 CST 2017, time=2017-10-13, status=1, ipAttribution=)]
    2018-07-20 minlingfeng
  2. [GetPortalCommentsPageByObjectIdResponse(id=1865146, encodeId=b16c18651469b, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri Jul 20 04:41:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255141, encodeId=5074255141a3, content=不错的.学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Oct 22 19:12:40 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254283, encodeId=75a0254283e8, content=非常好.学习了.很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Oct 19 11:36:34 CST 2017, time=2017-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253346, encodeId=157125334661, content=很好很好很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/07/8c1e5a0085f3b74f3a4ab58a38a3d487.jpg, createdBy=b33e2159612, createdName=2227437833_79976374, createdTime=Mon Oct 16 08:16:30 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253178, encodeId=0dfd2531e8f7, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/01/a422505c84c5bd7df245dee314debefc.jpg, createdBy=31332101574, createdName=kalery, createdTime=Sun Oct 15 18:19:19 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253002, encodeId=f65b25300264, content=好的.谢谢分享下.mark, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/mzZkwf53jx0oribz8WkmVTPTSib4iaRMXz6nkEOaqWPjgyYWQoLa8J2WCicWvb8SrhhZz5sgUcwmQnMQ1lJcA7Fhxg/0, createdBy=9b182084756, createdName=yunger, createdTime=Sun Oct 15 06:51:59 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252633, encodeId=4738252633e4, content=肝癌死亡率下降.得利于乙肝预防., beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri Oct 13 20:49:07 CST 2017, time=2017-10-13, status=1, ipAttribution=)]
    2017-10-22 虈亣靌

    不错的.学习了!谢谢分享!

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1865146, encodeId=b16c18651469b, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Fri Jul 20 04:41:00 CST 2018, time=2018-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=255141, encodeId=5074255141a3, content=不错的.学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Sun Oct 22 19:12:40 CST 2017, time=2017-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254283, encodeId=75a0254283e8, content=非常好.学习了.很受益, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Thu Oct 19 11:36:34 CST 2017, time=2017-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253346, encodeId=157125334661, content=很好很好很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/10/07/8c1e5a0085f3b74f3a4ab58a38a3d487.jpg, createdBy=b33e2159612, createdName=2227437833_79976374, createdTime=Mon Oct 16 08:16:30 CST 2017, time=2017-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253178, encodeId=0dfd2531e8f7, content=好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/01/a422505c84c5bd7df245dee314debefc.jpg, createdBy=31332101574, createdName=kalery, createdTime=Sun Oct 15 18:19:19 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=253002, encodeId=f65b25300264, content=好的.谢谢分享下.mark, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/mzZkwf53jx0oribz8WkmVTPTSib4iaRMXz6nkEOaqWPjgyYWQoLa8J2WCicWvb8SrhhZz5sgUcwmQnMQ1lJcA7Fhxg/0, createdBy=9b182084756, createdName=yunger, createdTime=Sun Oct 15 06:51:59 CST 2017, time=2017-10-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=252633, encodeId=4738252633e4, content=肝癌死亡率下降.得利于乙肝预防., beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Fri Oct 13 20:49:07 CST 2017, time=2017-10-13, status=1, ipAttribution=)]
    2017-10-19 虈亣靌

    非常好.学习了.很受益

    0

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    2017-10-16 2227437833_79976374

    很好很好很好

    0

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    2017-10-15 kalery

    好文章学习了

    0

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    2017-10-15 yunger

    好的.谢谢分享下.mark

    0

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    2017-10-13 1e0f8808m18(暂无匿称)

    肝癌死亡率下降.得利于乙肝预防.

    0

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