J Rheumatol:类风湿性关节炎的心血管事件风险高于2型糖尿病

2019-05-22 xiangting MedSci原创

RA的CV事件发病率是一般人群的2倍多。RA患者的CV风险比DM患者还高。

类风湿性关节炎(RA)的血管(CV)疾病风险增加。然而,调查这种风险的长期随访研究很少。

CARRE是一项前瞻性队列研究,调查了353例长期RA患者的CV疾病及其危险因素。在基线、研究开始后3、10和15年评估CV终点,并与参考队列(n=2540)进行比较,参考队列包括大量2型糖尿病(DM)患者。

2973人-年内,95例RA患者发生了CV事件,发病率为每100人-年3.20。参考队列在18874人-年内报告了257例CV事件,发病率为每100人-年1.36。与非糖尿病参与者相比,RA(HR 2.07,95%CI 1.57-2.72,P<0.01)和DM(HR 1.51,95%CI 1.02-2.22,P=0.04)CV事件的年龄和性别调整危险率(HR)增加。在对CV风险因素进行额外调整后,RA的HR仍然增加(HR 1.82,95%CI 1.32-2.50,P<0.01)。同时有RA和DM或胰岛素抵抗的患者出现CV疾病的HR最高(分别为2.21,95%CI 1.01-4.80,P=0.046和2.67,95%CI 1.30-5.46,P<0.01)。

RA的CV事件发病率是一般人群的2倍多。RA患者的CV风险比DM患者还高。调整传统CV风险因素后这种风险仍然存在,这表明全身性炎症是CV风险的独立因素。

原始出处:

R. Agca. Cardiovascular Event Risk in Rheumatoid Arthritis is Higher than in Type 2 Diabetes: a 15 Year Longitudinal Study. J Rheumatol. 15 May 2019.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

  


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    2019-05-24 lmm397
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    2019-05-24 zhouqu_8
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    2019-05-22 misszhang

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