Nature Reviews Cancer:抗癌药物直达肿瘤新技术

2015-05-28 佚名 生物谷

肿瘤在生物体内复杂的微环境结构影响到药物的扩散和分布,也让药物敏感性和肿瘤应答的研究较为困难。为了解决这个问题,研究者们最近开发出两种不同的新技术,可以将多种抗癌药物直接运送至肿瘤部位,研究药物分布和细胞毒性。最新一期的《Nature Review Cancer》杂志对此进行了介绍。 麻省理工(MIT)的Jonas等人研制出的小型圆柱载体包含了16个储藏小室。该载体可以用标准活检针直接植入老

肿瘤在生物体内复杂的微环境结构影响到药物的扩散和分布,也让药物敏感性和肿瘤应答的研究较为困难。为了解决这个问题,研究者们最近开发出两种不同的新技术,可以将多种抗癌药物直接运送至肿瘤部位,研究药物分布和细胞毒性。最新一期的《Nature Review Cancer》杂志对此进行了介绍。

麻省理工(MIT)的Jonas等人研制出的小型圆柱载体包含了16个储藏小室。该载体可以用标准活检针直接植入老鼠体内的肿瘤部位,并停留24个小时。储藏小室之间相互分开,可以用来装入不同的药物。药物通过被动运输迅速释放至周围的肿瘤组织,之后再用更大的针移除该装置及其周围组织,进而检测癌细胞对药物的反应。研究者们已经用此装置检测了阿霉素在内的多种药物在异种移植的人乳腺癌模型里的分布,给药浓度和肿瘤应答。

与此同时,来自西雅图Presage Biosciences的研究人员Klinghoffer等人创新发明的CIVO微注射技术,可以通过皮肤注射多达八种不同药物到肿瘤内。CIVO装置包含数个微型针头,每一个针头包含一种药物以及惰性示踪染料。在原位注射药物之后,肿瘤组织被切下,该产品自带的自动分析装置将检测药物在癌细胞内的作用。目前,CIVO在四名病人体内的初步实验显示其具有良好的安全性,更大规模的临床实验即将展开。

这两种新技术在未来拥有着广泛用途,包括药物的细胞穿透性和稳定性评估,药物的筛选,以及临床实验中药物最适浓度的选择等。

原始出处:

M. Teresa Villanueva.Get in there!Nature Reviews Cancer, May 22, 2015.doi:10.1038/nrc3963

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  1. 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GetPortalCommentsPageByObjectIdResponse(id=59868, encodeId=a2275986832, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 17:01:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1741264, encodeId=2e591e41264a2, content=<a href='/topic/show?id=329f1540333' target=_blank style='color:#2F92EE;'>#reviews#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15403, encryptionId=329f1540333, topicName=reviews)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9be134907862, createdName=12498ebem30暂无昵称, createdTime=Sat Jul 25 16:12:00 CST 2015, time=2015-07-25, status=1, ipAttribution=), 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createdName=lixiao3326, createdTime=Mon May 02 08:12:00 CST 2016, time=2016-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25586, encodeId=6a612558628, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun May 31 21:18:00 CST 2015, time=2015-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308211, encodeId=744b1308211cf, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Sat May 30 00:12:00 CST 2015, time=2015-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314631, encodeId=104813146318c, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat May 30 00:12:00 CST 2015, time=2015-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25202, encodeId=958a252020f, content=科技先进啊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Thu May 28 16:20:00 CST 2015, time=2015-05-28, status=1, ipAttribution=)]
    2016-04-13 liye789132251
  2. 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createdBy=4c0c1612254, createdName=summer474cn, createdTime=Thu May 28 16:20:00 CST 2015, time=2015-05-28, status=1, ipAttribution=)]
    2016-01-26 doctording1

    这篇文章有一定深度

    0

  3. 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createdBy=4c0c1612254, createdName=summer474cn, createdTime=Thu May 28 16:20:00 CST 2015, time=2015-05-28, status=1, ipAttribution=)]
    2016-01-26 doctording1

    是一篇不错的文章

    0

  4. 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createdName=lixiao3326, createdTime=Mon May 02 08:12:00 CST 2016, time=2016-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25586, encodeId=6a612558628, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun May 31 21:18:00 CST 2015, time=2015-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308211, encodeId=744b1308211cf, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Sat May 30 00:12:00 CST 2015, time=2015-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314631, encodeId=104813146318c, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat May 30 00:12:00 CST 2015, time=2015-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25202, encodeId=958a252020f, content=科技先进啊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Thu May 28 16:20:00 CST 2015, time=2015-05-28, status=1, ipAttribution=)]
  5. [GetPortalCommentsPageByObjectIdResponse(id=1880677, encodeId=b50618806e750, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Apr 13 03:12:00 CST 2016, time=2016-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59867, encodeId=40875986ec9, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 17:01:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59868, encodeId=a2275986832, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 17:01:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1741264, encodeId=2e591e41264a2, content=<a href='/topic/show?id=329f1540333' target=_blank style='color:#2F92EE;'>#reviews#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15403, encryptionId=329f1540333, topicName=reviews)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9be134907862, createdName=12498ebem30暂无昵称, createdTime=Sat Jul 25 16:12:00 CST 2015, time=2015-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995808, encodeId=6f2819958081d, content=<a href='/topic/show?id=a1751540260' target=_blank style='color:#2F92EE;'>#review#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15402, encryptionId=a1751540260, topicName=review)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Thu Apr 14 04:12:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1903694, encodeId=098f1903694ae, content=<a href='/topic/show?id=be285836438' target=_blank style='color:#2F92EE;'>#新技术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58364, encryptionId=be285836438, topicName=新技术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d39f177, createdName=lixiao3326, createdTime=Mon May 02 08:12:00 CST 2016, time=2016-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25586, encodeId=6a612558628, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun May 31 21:18:00 CST 2015, time=2015-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308211, encodeId=744b1308211cf, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Sat May 30 00:12:00 CST 2015, time=2015-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314631, encodeId=104813146318c, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat May 30 00:12:00 CST 2015, time=2015-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25202, encodeId=958a252020f, content=科技先进啊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Thu May 28 16:20:00 CST 2015, time=2015-05-28, status=1, ipAttribution=)]
    2016-04-14 xugumin
  6. [GetPortalCommentsPageByObjectIdResponse(id=1880677, encodeId=b50618806e750, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Apr 13 03:12:00 CST 2016, time=2016-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59867, encodeId=40875986ec9, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 17:01:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), 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GetPortalCommentsPageByObjectIdResponse(id=1995808, encodeId=6f2819958081d, content=<a href='/topic/show?id=a1751540260' target=_blank style='color:#2F92EE;'>#review#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15402, encryptionId=a1751540260, topicName=review)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Thu Apr 14 04:12:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1903694, encodeId=098f1903694ae, content=<a href='/topic/show?id=be285836438' target=_blank style='color:#2F92EE;'>#新技术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58364, encryptionId=be285836438, topicName=新技术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d39f177, createdName=lixiao3326, createdTime=Mon May 02 08:12:00 CST 2016, time=2016-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25586, encodeId=6a612558628, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun May 31 21:18:00 CST 2015, time=2015-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308211, encodeId=744b1308211cf, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Sat May 30 00:12:00 CST 2015, time=2015-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314631, encodeId=104813146318c, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat May 30 00:12:00 CST 2015, time=2015-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25202, encodeId=958a252020f, content=科技先进啊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Thu May 28 16:20:00 CST 2015, time=2015-05-28, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1880677, encodeId=b50618806e750, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Apr 13 03:12:00 CST 2016, time=2016-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59867, encodeId=40875986ec9, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 17:01:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59868, encodeId=a2275986832, content=是一篇不错的文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 17:01:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1741264, encodeId=2e591e41264a2, content=<a href='/topic/show?id=329f1540333' target=_blank style='color:#2F92EE;'>#reviews#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15403, encryptionId=329f1540333, topicName=reviews)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9be134907862, createdName=12498ebem30暂无昵称, createdTime=Sat Jul 25 16:12:00 CST 2015, time=2015-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1995808, encodeId=6f2819958081d, content=<a href='/topic/show?id=a1751540260' target=_blank style='color:#2F92EE;'>#review#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15402, encryptionId=a1751540260, topicName=review)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=xugumin, createdTime=Thu Apr 14 04:12:00 CST 2016, time=2016-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1903694, encodeId=098f1903694ae, content=<a href='/topic/show?id=be285836438' target=_blank style='color:#2F92EE;'>#新技术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58364, encryptionId=be285836438, topicName=新技术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d39f177, createdName=lixiao3326, createdTime=Mon May 02 08:12:00 CST 2016, time=2016-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25586, encodeId=6a612558628, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun May 31 21:18:00 CST 2015, time=2015-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308211, encodeId=744b1308211cf, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Sat May 30 00:12:00 CST 2015, time=2015-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314631, encodeId=104813146318c, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat May 30 00:12:00 CST 2015, time=2015-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25202, encodeId=958a252020f, content=科技先进啊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Thu May 28 16:20:00 CST 2015, time=2015-05-28, status=1, ipAttribution=)]
    2015-05-31 huaxipanxing

    看看

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1880677, encodeId=b50618806e750, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Apr 13 03:12:00 CST 2016, time=2016-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59867, encodeId=40875986ec9, content=这篇文章有一定深度, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59121683644, createdName=doctording1, createdTime=Tue Jan 26 17:01:00 CST 2016, time=2016-01-26, status=1, ipAttribution=), 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createdName=lixiao3326, createdTime=Mon May 02 08:12:00 CST 2016, time=2016-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25586, encodeId=6a612558628, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sun May 31 21:18:00 CST 2015, time=2015-05-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1308211, encodeId=744b1308211cf, content=<a href='/topic/show?id=6e495554550' target=_blank style='color:#2F92EE;'>#抗癌药物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55545, encryptionId=6e495554550, topicName=抗癌药物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=9fe6351, createdName=flyingeagle77, createdTime=Sat May 30 00:12:00 CST 2015, time=2015-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1314631, encodeId=104813146318c, content=<a href='/topic/show?id=9d4b5554131' target=_blank style='color:#2F92EE;'>#抗癌药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55541, encryptionId=9d4b5554131, topicName=抗癌药)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat May 30 00:12:00 CST 2015, time=2015-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=25202, encodeId=958a252020f, content=科技先进啊!, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://api.medsci.cn/resource/upload/20150526/IMG5564536F3C41D5237.jpg, createdBy=4c0c1612254, createdName=summer474cn, createdTime=Thu May 28 16:20:00 CST 2015, time=2015-05-28, status=1, ipAttribution=)]
  9. 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createdBy=4c0c1612254, createdName=summer474cn, createdTime=Thu May 28 16:20:00 CST 2015, time=2015-05-28, status=1, ipAttribution=)]
    2015-05-30 sunylz
  10. 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createdBy=4c0c1612254, createdName=summer474cn, createdTime=Thu May 28 16:20:00 CST 2015, time=2015-05-28, status=1, ipAttribution=)]
    2015-05-28 summer474cn

    科技先进啊!

    0

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