BMC Gastroenterology: 倾向评分匹配分析口服乳果糖对复杂性阑尾炎患者的术后治疗效果的影响

2019-11-21 不详 MedSci原创

口服乳果糖被广泛用于胃肠功能调节。然而,关于口服乳果糖对近期术后胃肠道(GI)恢复和长期粘连性小肠梗阻(ASBO)发生率的影响,尤其是在术后儿科人群中,其临床益处尚不确定。因此,本项研究的目的是探究口服乳果糖对小儿阑尾炎并发阑尾切除术的疗效。

背景及目的
口服乳果糖被广泛用于肠功能调节。然而,关于口服乳果糖对近期术后肠道(GI)恢复和长期粘连性小肠梗阻(ASBO)发生率的影响,尤其是在术后儿科人群中,其临床益处尚不确定。因此,本项研究的目的是探究口服乳果糖对小儿阑尾炎并发阑尾切除术的疗效。

方法
研究人员回顾性分析了525例小儿并发阑尾炎的患者。其中317例接受口服乳果糖治疗,208例未接受口服乳果糖治疗。倾向得分1:1匹配以调整任何潜在的基线变量。在189例配对患者中,根据是否口服乳果糖比较了临床结果,包括胃肠道恢复变量,ABSO发生率以及不良事件发生的情况。

结果
本项研究显示口服乳果糖给药的患者可实现早期胃肠功能恢复,包括初次肠蠕动(RR为1.34; 95%[CI] 1.02–2.63,p= 0.005)和初次固体喂养(RR为1.26; 95%CI,1.01-1.92,p= 0.012)。同时研究发现,口服乳果糖给药的患儿ASBO的发生率较低(OR为0.47; 95%CI为0.25–0.87;p ?= 0.011),便秘发生率较低([OR]为0.25; 95%CI为0.13–0.46;p ?<0.001)。此外,需要再入院(OR,0.56; 95%CI,0.32-0.99;p= 0.031)和再次手术(OR,0.29; 95%CI,0.09-0.92;p= 0.022)在接受口服乳果糖的患者中均明显减少。

结论
口服乳果糖对小儿阑尾切除术患者有益,如加速胃肠功能恢复,减少ASBO和便秘的发生率,从而减少再入院和再次手术。

原始出处:

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    2020-09-04 许安
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  5. 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  6. 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  7. 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  8. 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    2019-11-22 txqjm

    谢谢了,学习

    0

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