Int J Mol Sci:磷酸化羟基磷灰石薄膜可提高植体表面成骨活性

2018-04-14 MedSci MedSci原创

为了增强生物相容性/成骨作用和骨结合,我们通过氟化氪(KrF)脉冲激光沉积对钛植体表面涂覆氟化羟基磷灰石(FHA)薄膜。 通过扫描电子显微镜(SEM)和扫描探针显微镜(SPM)确认涂层涂覆成功,同时通过衰减反射傅立叶变换红外光谱(ATR-FTIR)评估涂层的物理化学性质。 结果显示,接种在FHA包被的钛表面的大鼠骨髓间充质干细胞中的钙沉积、骨钙蛋白产生和成骨细胞基因的表达明显高于接种在未包被的钛表

为了增强生物相容性/成骨作用和骨结合,我们通过氟化氪(KrF)脉冲激光沉积对钛植体表面涂覆氟化羟基磷灰石(FHA)薄膜。

通过扫描电子显微镜(SEM)和扫描探针显微镜(SPM)确认涂层涂覆成功,同时通过衰减反射傅立叶变换红外光谱(ATR-FTIR)评估涂层的物理化学性质。

结果显示,接种在FHA包被的钛表面的大鼠骨髓间充质干细胞中的钙沉积、骨钙蛋白产生和成骨细胞基因的表达明显高于接种在未包被的钛表面的细胞。植入大鼠股骨,微型计算机断层摄影术和组织学评估显示,与传统植入物相比,FHA包被的材料具有优异的骨诱导和骨整合活性。

因此,涂有FHA的钛具有作为牙科植入物材料的前景。

原始出处:

Chen L, Komasa S, et al., In Vitro and In Vivo Osteogenic Activity of Titanium Implants Coated by Pulsed Laser Deposition with a Thin Film of Fluoridated Hydroxyapatite. Int J Mol Sci. 2018 Apr 10;19(4). pii: E1127. doi: 10.3390/ijms19041127.

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    2018-04-19 杨柳青青

    签到学习了--

    0

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    2018-04-16 杨柳青青

    签到学习了--

    0

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    2018-04-16 zhaojie88
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    2018-04-15 方舒

    学习

    0

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    2018-04-14 清风拂面

    谢谢分享学习

    0

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    2018-04-14 wqkm

    ^_^^_^^_^^_^

    0

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    2018-04-14 杨柳青青

    签到学习了--

    0