Neurology:坚持地中海饮食可有效延缓中年人群脑AD标志物进展

2018-04-16 zhangfan MedSci原创

研究认为,中年人群坚持地中海饮食可有效的延缓AD进展风险,高依从性人群的收益更为显著

近日研究人员开展为期3年的研究,考察了地中海饮食(MeDi)依从性对中年人群阿尔兹海默脑生物标志物的影响。

70名30-60岁认知正常的参与者进行了至少2年的临床、神经心理学、饮食和影像生物标记检查,其中34人定义为地中海饮食高依从性人群(MeDi+),36人为低依从性人群(MeDi-),利用11C-匹兹堡复合物PET检查患者脑β-淀粉样蛋白积累,利用18F-脱氧葡萄糖(FDG)PET和结构磁共振成像考察神经变性。

参与者基线临床和神经心理检查结果具有可比性。基线时,相比于MeDi+人群,MeDi-组,FDG-PET糖代谢减少,PiB-PET显示受AD影响区域β-淀粉样蛋白积累较高(p < 0.001)。纵向随访研究发现,MeDi-组糖代谢减少,匹兹堡复合物响应增加。组间结构MRI差异不显著。高地中海饮食依从性可导致中年AD高风险人群AD显著临床进展延缓1.5-3.5年。

研究认为,中年人群坚持地中海饮食可有效的延缓AD进展风险,高依从性人群的收益更为显著。

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    2018-09-25 yinhl1978
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    2018-04-19 健康达人

    地中海饮食是热点,被认为是最健康的饮食,而中国传统饮食一般被认为多半是不健康的,这是事实吗?其实需要更多严谨的科学证据,而不是猜测!

    0

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    2018-04-19 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

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    2018-04-19 121832a9m88暂无昵称

    学习了

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    2018-04-18 wgx311

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