NEJM:粪类圆线虫重度感染-案例报道

2017-06-15 xing.T MedSci原创

虽然肠道线虫S.线虫可以保持沉默,但免疫抑制可导致感染综合征,其特点是在蠕虫负担大幅增加,伴有器官浸润。侵入肠壁可促进细菌移位,对于那些来自或前往一个寄生虫流行的地方的个体,在免疫抑制治疗之前应考虑检测和经验治疗S.线虫,以减少感染综合征的风险。

患者为一名47岁男性,曾经生活在老挝,服用强的松治疗皮肌炎,该患者有腹痛、黑便、发热、咯血4天以及出现皮疹2周。就诊前一个月,该患者入院并接受大剂量糖皮质激素治疗弥漫性肺泡出血。出血原因尚不明确,但采用糖皮质激素治疗患者病情得到改善。

这次就诊时,患者出现低血压和心动过速;体检发现在腹部有网状紫癜性斑块,伴有较为灰暗的中心,延伸到侧面、腹股沟、阴茎、大腿(如图A所示)。进展性呼吸窘迫,该患者接受气管插管。支气管镜检查显示弥漫性肺泡出血,发现粪类圆线虫的幼虫。皮疹活检发现丝状幼虫(如图B箭头所示)和寄生虫分布在真皮胶原纤维束之间。血培养得到粪肠球菌和肺炎克雷伯菌。



虽然肠道线虫S.线虫可以保持沉默,但免疫抑制可导致感染综合征,其特点是在蠕虫负担大幅增加,伴有器官浸润。侵入肠壁可促进细菌移位,对于那些来自或前往一个寄生虫流行的地方的个体,在免疫抑制治疗之前应考虑检测和经验治疗S.线虫,以减少感染综合征的风险。

除了进行针对多种微生物引起的菌血症抗生素治疗外,该患者采用伊维菌素和阿苯达唑治疗,最后,该患者完全康复。

原始出处:

Heidi H. McDonald,et al. Strongyloides stercoralis Hyperinfection.N Engl J Med 2017; http://www.nejm.org/doi/full/10.1056/NEJMicm1612018

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1493419, encodeId=9b70149341998, content=<a href='/topic/show?id=ebbbe7621c7' target=_blank style='color:#2F92EE;'>#线虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77621, encryptionId=ebbbe7621c7, topicName=线虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=133b9055992, createdName=zblhy, createdTime=Fri Jun 16 23:07:00 CST 2017, time=2017-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211053, encodeId=afe321105385, content=典型病例,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Jun 15 09:06:47 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211013, encodeId=e279211013d4, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Jun 15 08:12:52 CST 2017, time=2017-06-15, status=1, ipAttribution=)]
    2017-06-16 zblhy
  2. [GetPortalCommentsPageByObjectIdResponse(id=1493419, encodeId=9b70149341998, content=<a href='/topic/show?id=ebbbe7621c7' target=_blank style='color:#2F92EE;'>#线虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77621, encryptionId=ebbbe7621c7, topicName=线虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=133b9055992, createdName=zblhy, createdTime=Fri Jun 16 23:07:00 CST 2017, time=2017-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211053, encodeId=afe321105385, content=典型病例,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Jun 15 09:06:47 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211013, encodeId=e279211013d4, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Jun 15 08:12:52 CST 2017, time=2017-06-15, status=1, ipAttribution=)]
    2017-06-15 1e0f8808m18(暂无匿称)

    典型病例,学习了。

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1493419, encodeId=9b70149341998, content=<a href='/topic/show?id=ebbbe7621c7' target=_blank style='color:#2F92EE;'>#线虫#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77621, encryptionId=ebbbe7621c7, topicName=线虫)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=133b9055992, createdName=zblhy, createdTime=Fri Jun 16 23:07:00 CST 2017, time=2017-06-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211053, encodeId=afe321105385, content=典型病例,学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Thu Jun 15 09:06:47 CST 2017, time=2017-06-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=211013, encodeId=e279211013d4, content=谢谢分享,学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Jun 15 08:12:52 CST 2017, time=2017-06-15, status=1, ipAttribution=)]
    2017-06-15 明月清辉

    谢谢分享,学习了

    0