Hypertension:妊娠期高血压疾病后心血管危险因素的变化轨迹

2018-11-13 xing.T MedSci原创

由此可见,该研究的数据支持在40岁前对患有HDP病史的女性进行心血管随访。

高血压疾病(HDP)女性患血管疾病的风险增加。血管风险管理指南强调了这些女性预防心血管疾病的必要性,但未能就何时以及如何开始心血管风险评估提供统一的建议。近日,心血管权威杂志Hypertension上发表了一篇研究文章,这项研究的目的是确定一个机会窗,通过调查既往有HDP病史的女性血压、血脂和空腹血糖水平随时间的变化来进行心血管危险因素评估。

在基于高风险人群的队列研究中,研究人员确定了正常血压妊娠女性(n=1811)或HDP女性(n=1005),并进行了5次测量,每隔3年评估一次血压、血脂以及血糖变化,10年心血管风险以及高血压、血脂异常和糖尿病的发生率。使用广义估计方程进行统计分析,以年龄作为时间变量,使用最小显著性差异方法调整多重比较。

在患有HDP的女性中,高血压(P<0.0001)、血脂异常(P=0.003)和糖尿病(P<0.0001)的总体患病率显著增高。他们患有高血压和糖尿病的时间也更早。在35岁时,很少有HDP女性需要进行筛查以检测临床相关的高血压:需要对9名女性进行筛查以检测1名有治疗指征的女性,而正常血压妊娠女性需要38名。

由此可见,该研究的数据支持在40岁前对患有HDP病史的女性进行心血管随访。

原始出处:

T. Katrien J.,et al.Trajectory of Cardiovascular Risk Factors After Hypertensive Disorders of Pregnancy An Argument for Follow-Up.Hypertension.2018. https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.118.11726

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    2019-06-16 feather89
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    2018-11-13 一个字-牛

    学习了谢谢分享

    0

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