Radiology:MR肠道成像定量评价回肠末端蠕动在诊断克罗恩病活动性的价值

2019-03-19 shaosai MedSci原创

本研究旨在利用MRI定量小肠蠕动来评价克罗恩病活动性,并与参考标准内镜和组织病理学结果相比较。

本研究旨在利用MRI定量小肠蠕动来评价克罗恩病活动性,并与参考标准内镜和组织病理学结果相比较。

本研究共纳入了82例克罗恩病并行结肠镜和MR肠道成像的患者。对回肠末端进行克内镜下罗恩病严重指数(CDEIS)、组织病理学活动性评分(内镜下活检急性组织学炎症评分[EAIS] )、活动性MR指数(MaRIA)评价。利用图像匹配基于蠕动评价算法对回肠末端蠕动性进行评价。利用McNemar检验比较提示病变活动(CDEIS ≥4 或EAIS ≥1)蠕动性(>0.3任意单位)和MaRIA (≥7、≥11)的敏感性和特异性。比较两者ROC曲线下面积。利用Spearman等级评价比较蠕动性与参考标准的相关性。

结果为,回肠末端蠕动性与EAIS (r =-0.61; 95%CI: 0.7, -0.5)和CDEIS(r = -0.59; 95% CI: 0.7, -0.4)具有负性相关。以CDEIS为参考标准,蠕动性的敏感性要高于MaRIA (≥11) (93% vs 78%,P = .03),但其特异性要低于后者(61% vs 81%; P = .04)。以EAIS为参考标准,蠕动性的敏感性要高于MaRIA (≥7) (92% vs 75%; P = .03),但两者具有相似的敏感性(71% vs 74%; P >.99)。分别以CDEIS、EAIS为参考标准,蠕动性的ROC曲线下面积分别为0.86、0.87。

本研究表明对于克罗恩病末端回肠蠕动性评分与肠镜、组织病理学病变活动性具有较好一致性。

原始出处:

Menys A, Puylaert C, Tutein Nolthenius CE,et al.Quantified Terminal Ileal Motility during MR Enterography as a Biomarker of Crohn Disease Activity: Prospective Multi-Institution Study.Radiology.DOI:10.1148/radiol.2018180100

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    2019-03-21 huagfeg
  3. [GetPortalCommentsPageByObjectIdResponse(id=1723960, encodeId=bd7c1e239605f, content=<a href='/topic/show?id=2d996516e7c' target=_blank style='color:#2F92EE;'>#活动性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65167, encryptionId=2d996516e7c, topicName=活动性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Wed Nov 20 17:09:00 CST 2019, time=2019-11-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1444523, encodeId=b35c1444523c8, content=<a href='/topic/show?id=3d9291459d1' target=_blank style='color:#2F92EE;'>#评价#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91459, encryptionId=3d9291459d1, topicName=评价)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1fee5134542, createdName=huagfeg, createdTime=Thu Mar 21 14:09:00 CST 2019, time=2019-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1511346, encodeId=78c1151134682, content=<a href='/topic/show?id=d47d40542cc' target=_blank style='color:#2F92EE;'>#回肠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40542, encryptionId=d47d40542cc, topicName=回肠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b1110335485, createdName=Tamikia, createdTime=Thu Mar 21 14:09:00 CST 2019, time=2019-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=363235, encodeId=a21c363235f1, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRkia1DP5MpwEgtXo1XhXA11xD6MWKxunAZFXKSNic0fWHUQx83oNHPlRMxxIctM83QKeCLkJpMibibiaC/0, createdBy=7e581734408, createdName=深海的鱼, createdTime=Wed Mar 20 06:29:08 CST 2019, time=2019-03-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=363224, encodeId=3653363224f0, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Tue Mar 19 23:28:26 CST 2019, time=2019-03-19, status=1, ipAttribution=)]
    2019-03-21 Tamikia
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    2019-03-20 深海的鱼

    学习学习学习

    0

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    2019-03-19 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0