JCO:乳腺癌人群C反应蛋白与放疗导致的皮肤不良反应之间的关系

2018-07-12 MedSci MedSci原创

JCO近期发表了一篇文章,研究乳腺癌人群中炎性标志物,高灵敏度C反应蛋白(hsCRP)与放疗导致的早期皮肤不良反应或毒性之间的关系。

JCO近期发表了一篇文章,研究乳腺癌人群中炎性标志物,高灵敏度C反应蛋白(hsCRP)与放疗导致的早期皮肤不良反应或毒性之间的关系。

作者分析了2001年到2013年间接受放疗的1000例乳腺癌患者,收集患者治疗前和治疗后血浆hsCRP水平,使用ONS皮肤毒性评价标准评估放疗导致的皮肤毒性。使用多因素logistic回归分析研究hsCRP水平与放疗导致的皮肤毒性之间的关系。1000例患者中包括623例白人,280例非裔美国人,64例亚洲人和33例其他种族人群。24%的患者为西班牙裔,47%的患者肥胖。约42%的患者出现放疗诱导的3级皮肤毒性,约15%的患者出现放疗诱导的4级皮肤毒性。不同人种和BMI的患者hsCRP水平显着不同。多因素分析表明,4级皮肤毒性与肥胖,放疗后hsCRP水平和两者联合显着相关。在非肥胖患者中,中位放疗后hsCRP水平以上以及hsCRP改变与4级皮肤毒性显着相关。

文章最后认为,该研究结果证明hsCRP可以作为乳腺癌放疗导致的皮肤毒性的炎症标志物。非肥胖人群hsCRP水平升高会显着增加4级皮肤毒性风险。这些结果有助于预测放疗反应及临床决策。

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    2018-09-29 lidong40
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    2018-07-14 大爰

    学习了谢谢分享!!

    0

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