Lancet:新一代药物洗脱支架植入较裸金属支架在预后及安全性方面更具优势

2019-05-11 MedSci MedSci原创

新一代药物洗脱支架植入后的安全性与裸金属支架相当,并且长期预后更具优势

涉及新一代药物洗脱支架(DES)的临床研究主要以早期DES为头对头非劣性试验对象,并且具有出相似的疗效和优越的安全性。与裸金属支架(BMS)相比,新一代DES的安全状况尚不清楚。

近日研究人员对患者进行了随机临床试验的个体数据荟萃分析,比较经皮冠状动脉介入治疗的患者在植入新一代DES 或BMS后的结果,主要终点是心源性死亡或心肌梗死

20个随机试验中,包含26616名患者的个体数据,平均随访3.2年。与BMS患者相比,DES患者的主要预后风险降低 (0.79),心肌梗死风险降低(0.79),并可能有轻微但不显著的心脏死亡率降低收益(0.89),全死因死亡未受影响(0.96),但支架血栓形成(0.63)和靶血管重建(0.55)的风险降低。研究人员发现临床收益存在时间依赖性,植入后1年,DES与BMS相比,主要结果的风险较低,上述效果长期保持。

研究认为,新一代药物洗脱支架植入后的安全性与裸金属支架相当,并且长期预后更具优势。

原始出处:


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    2019-07-14 gous
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encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Mar 03 00:31:00 CST 2020, time=2020-03-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1935169, encodeId=88391935169b1, content=<a href='/topic/show?id=49455e1086e' target=_blank style='color:#2F92EE;'>#支架植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=57108, encryptionId=49455e1086e, topicName=支架植入)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=70fe497, createdName=paperyu, createdTime=Fri Jun 28 02:31:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310500, encodeId=c62813105003a, content=<a href='/topic/show?id=f70e8e78941' target=_blank style='color:#2F92EE;'>#药物洗脱支架#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87789, encryptionId=f70e8e78941, topicName=药物洗脱支架)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=86b7385, createdName=lqrandywkz, createdTime=Mon May 13 10:31:00 CST 2019, time=2019-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520584, encodeId=9dc6152058483, content=<a href='/topic/show?id=7a736264553' target=_blank style='color:#2F92EE;'>#植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62645, encryptionId=7a736264553, topicName=植入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=832411313664, createdName=jiyangfei, createdTime=Mon May 13 10:31:00 CST 2019, time=2019-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366101, encodeId=b3d0366101cd, content=非常好的文章,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaELCAs1uRBgDoWqJaBltta2Y7fTibyM6wYf94osSMg5CCm9oy7JrdcXPqh1DrCdn5IxO4BE8ZLEiaQXQ/0, createdBy=978a1675334, createdName=xiaogan8479, createdTime=Sun May 12 12:01:31 CST 2019, time=2019-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366090, encodeId=f7c2366090f3, content=这个结论是大家一致的,只是荟萃了以往的研究,结果可能更加平均而己, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun May 12 08:46:55 CST 2019, time=2019-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366056, encodeId=6ade366056d5, content=学习,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sat May 11 21:16:10 CST 2019, time=2019-05-11, status=1, ipAttribution=)]
    2020-03-03 howi
  5. 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objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sat May 11 21:16:10 CST 2019, time=2019-05-11, status=1, ipAttribution=)]
  6. 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level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87789, encryptionId=f70e8e78941, topicName=药物洗脱支架)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=86b7385, createdName=lqrandywkz, createdTime=Mon May 13 10:31:00 CST 2019, time=2019-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520584, encodeId=9dc6152058483, content=<a href='/topic/show?id=7a736264553' target=_blank style='color:#2F92EE;'>#植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62645, encryptionId=7a736264553, topicName=植入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=832411313664, createdName=jiyangfei, createdTime=Mon May 13 10:31:00 CST 2019, time=2019-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366101, encodeId=b3d0366101cd, content=非常好的文章,谢谢分享, 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objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sat May 11 21:16:10 CST 2019, time=2019-05-11, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1926590, encodeId=2ed91926590c7, content=<a href='/topic/show?id=4c19961e039' target=_blank style='color:#2F92EE;'>#金属支架#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96170, encryptionId=4c19961e039, topicName=金属支架)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7a9987, createdName=gous, createdTime=Sun Jul 14 07:31:00 CST 2019, time=2019-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1990202, encodeId=d1a31990202a9, content=<a href='/topic/show?id=94fc9043603' target=_blank style='color:#2F92EE;'>#裸金属支架#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90436, encryptionId=94fc9043603, topicName=裸金属支架)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=25e7304, 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level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87789, encryptionId=f70e8e78941, topicName=药物洗脱支架)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=86b7385, createdName=lqrandywkz, createdTime=Mon May 13 10:31:00 CST 2019, time=2019-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520584, encodeId=9dc6152058483, content=<a href='/topic/show?id=7a736264553' target=_blank style='color:#2F92EE;'>#植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62645, encryptionId=7a736264553, topicName=植入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=832411313664, createdName=jiyangfei, createdTime=Mon May 13 10:31:00 CST 2019, time=2019-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366101, encodeId=b3d0366101cd, content=非常好的文章,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaELCAs1uRBgDoWqJaBltta2Y7fTibyM6wYf94osSMg5CCm9oy7JrdcXPqh1DrCdn5IxO4BE8ZLEiaQXQ/0, createdBy=978a1675334, createdName=xiaogan8479, createdTime=Sun May 12 12:01:31 CST 2019, time=2019-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366090, encodeId=f7c2366090f3, content=这个结论是大家一致的,只是荟萃了以往的研究,结果可能更加平均而己, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun May 12 08:46:55 CST 2019, time=2019-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366056, encodeId=6ade366056d5, content=学习,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sat May 11 21:16:10 CST 2019, time=2019-05-11, status=1, ipAttribution=)]
    2019-05-13 jiyangfei
  8. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaELCAs1uRBgDoWqJaBltta2Y7fTibyM6wYf94osSMg5CCm9oy7JrdcXPqh1DrCdn5IxO4BE8ZLEiaQXQ/0, createdBy=978a1675334, createdName=xiaogan8479, createdTime=Sun May 12 12:01:31 CST 2019, time=2019-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366090, encodeId=f7c2366090f3, content=这个结论是大家一致的,只是荟萃了以往的研究,结果可能更加平均而己, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun May 12 08:46:55 CST 2019, time=2019-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366056, encodeId=6ade366056d5, content=学习,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sat May 11 21:16:10 CST 2019, time=2019-05-11, status=1, ipAttribution=)]
    2019-05-12 xiaogan8479

    非常好的文章,谢谢分享

    0

  9. 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level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87789, encryptionId=f70e8e78941, topicName=药物洗脱支架)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=86b7385, createdName=lqrandywkz, createdTime=Mon May 13 10:31:00 CST 2019, time=2019-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1520584, encodeId=9dc6152058483, content=<a href='/topic/show?id=7a736264553' target=_blank style='color:#2F92EE;'>#植入#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62645, encryptionId=7a736264553, topicName=植入)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=832411313664, createdName=jiyangfei, createdTime=Mon May 13 10:31:00 CST 2019, time=2019-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366101, encodeId=b3d0366101cd, content=非常好的文章,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/PiajxSqBRaELCAs1uRBgDoWqJaBltta2Y7fTibyM6wYf94osSMg5CCm9oy7JrdcXPqh1DrCdn5IxO4BE8ZLEiaQXQ/0, createdBy=978a1675334, createdName=xiaogan8479, createdTime=Sun May 12 12:01:31 CST 2019, time=2019-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366090, encodeId=f7c2366090f3, content=这个结论是大家一致的,只是荟萃了以往的研究,结果可能更加平均而己, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c4a5105539, createdName=lovetcm, createdTime=Sun May 12 08:46:55 CST 2019, time=2019-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=366056, encodeId=6ade366056d5, content=学习,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sat May 11 21:16:10 CST 2019, time=2019-05-11, status=1, ipAttribution=)]
    2019-05-12 lovetcm

    这个结论是大家一致的,只是荟萃了以往的研究,结果可能更加平均而己

    0

  10. 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objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Sat May 11 21:16:10 CST 2019, time=2019-05-11, status=1, ipAttribution=)]
    2019-05-11 天地飞扬

    学习,谢谢分享!

    0

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经皮冠状动脉介入治疗(PCI)中,药物洗脱支架(DES)被越来越多地用于大隐静脉移植狭窄的血运重建,但尚无有利于其使用的强有力临床证据。在大隐静脉移植行PCI的患者中,有关DES与裸金属支架(BMS)的随机对照试验尚无定论。Circulation:Cardiovascular Interventions发表的这项研究对此进行了探讨。

Lancet:ST段抬高心肌梗死患者使用依维莫司洗脱支架与裸金属支架治疗比较

新一代药物洗脱支架的在长期随访的安全性和疗效性数据,特别是对于ST段抬高心肌梗死患者的数据是稀缺的。在EXAMINATION试验中,研究人员比较了所有ST段抬高型心肌梗死患者使用依维莫司洗脱支架(EES)和裸金属支架(BMS)的效果。在这项研究中,研究人员评估了EXAMINATION人群的5年结果。该多中心EXAMINATION试验,在意大利,西班牙和荷兰进行,ST段抬高心肌梗死患者被随机分配以1