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Science：Pax3选择性聚腺苷酸化调控骨骼肌干细胞的动静转换

2019-11-09 不详 MedSci原创

骨骼肌干细胞Pax3聚腺苷酸化
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成体干细胞对组织内环境稳态至关重要。在骨骼肌中，肌肉干细胞(MuSCs)处于静止状态，在骨骼肌损伤后的再生过程中发挥作用，但对其控制体内平衡转变的机制知之甚少。 近期，研究人员发现在小鼠中，不同肌肉(如四肢肌肉和膈肌)之间的MuSC激活率的变化是由转录因子Pax3的水平决定的。而Pax3的水平是由其转录本的选择性聚腺苷酸化控制的，而聚腺苷酸化又是由小核仁RNA U1调控的。 Pax3

成体干细胞对组织内环境稳态至关重要。在骨骼肌中，肌肉干细胞(MuSCs)处于静止状态，在骨骼肌损伤后的再生过程中发挥作用，但对其控制体内平衡转变的机制知之甚少。

近期，研究人员发现在小鼠中，不同肌肉(如四肢肌肉和膈肌)之间的MuSC激活率的变化是由转录因子Pax3的水平决定的。而Pax3的水平是由其转录本的选择性聚腺苷酸化控制的，而聚腺苷酸化又是由小核仁RNA U1调控的。

Pax3 mRNA的亚型区别在于3 'UTR区差异，对小RNA miR206的调控具有不同的敏感性，从而导致Pax3蛋白的体内表达水平不同。

本研究结果强调了一个既往未被认识到的机制，即干细胞命运的自我调节是通过多种RNA完成的。

原始出处：

Antoine de Morree， et al.Alternative polyadenylation of Pax3 controls muscle stem cell fate and muscle function.Science. November， 08， 2019. Vol. 366， Issue 6466， pp. 734-738. DOI： 10.1126/science.aax1694

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    2020-09-09 肉我只吃一口

    #选择性#

    0

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    2020-02-20 hongbochen

    #骨骼肌干细胞#

    0

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    2019-11-12 独孤立克

    干细胞是热点，但是进入临床仍然需要时间和临床疗效验证哦

    0

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    2019-11-11 ms1065684921169360

    #骨骼肌#

    0

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    2019-11-11 jichang

    #SCIE#

    0

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