Lancet:肿瘤幸存者中长期心血管事件风险增加

2019-08-21 MedSci MedSci原创

与一般人群相比,大多数特定部位癌症幸存者患一种或多种心血管疾病的中长期风险增加,不同癌症之间差异很大

在过去的几十年里,癌症的存活率有了很大的提高,但是对于幸存者长期心血管疾病风险研究尚不充分。近日研究人员考察多个英国数据库对肿瘤人群的长期心血管风险进行了考察。研究考察了20个最常见癌症的幸存者的队列,癌症患者在18岁或以上,在诊断和疾病控制后12个月仍然存活。研究的主要终点为一系列心血管疾病风险。

126120名癌症患者参与研究,并与630144名对照组进行配对。与对照组相比,20个部位特异性肿瘤中,18个肿瘤幸存者的静脉血栓栓塞风险升高;调整后的危险比(HRs)从前列腺癌患者的1.72到胰腺癌患者的9.72。随着时间的推移,HRs逐渐下降,但在诊断5年后仍保持较高。研究人员观察到在20种癌症中,有10种心力衰竭或心肌病风险增加,调整后的HR :非霍奇金淋巴瘤为1.94、白血病为1.77、多发性骨髓瘤为3.29、食管癌为1.96、肺癌为1.82、肾癌为1.73而卵巢癌为1.59。在多种癌症,包括血液学恶性肿瘤中,也观察到心律失常、心包炎、冠状动脉疾病、中风和瓣膜性心脏病的风险升高。心衰或心肌病及静脉血栓栓塞的HRs在无基础心血管疾病的患者和年轻的患者中更大。

与一般人群相比,大多数特定部位癌症幸存者患一种或多种心血管疾病的中长期风险增加,不同癌症之间差异很大。

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    2020-02-16 howi
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    2019-08-22 thm112988

    0

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