CLIN CHEM:利用脱氧核酶传感器对非结核分枝杆菌进行菌种分型

2019-02-07 MedSci MedSci原创

结核分枝杆菌(NTM)是一种逐渐升级的威胁,特别是对于患有肺部合并症的患者。目前的床旁诊断无法充分识别和区分NTM物种与结核分枝杆菌(Mtb)。基于培养和分子的测试可能需要数周到数月的时间,并且需要将样品送到专门的诊断实验室。

在这个概念验证研究中,研究人员开发了一种基于PCR扩增16S核糖体RNArRNArrs基因的分析,使用通用的分枝杆菌引物和用一组二元脱氧核酶(BiDz)传感器对扩增片段进行查询 能够在物种水平鉴定NTMBiDz-NTM ST)。每个BiDz传感器由RNA切割脱氧核酶的2个亚基组成,其仅在存在互补靶序列的情况下形成活性脱氧核酶催化核心。靶活化的BiDz催化报道基质的切割,从而根据所用的底物触发荧光或比色(视觉观察)信号。该小组包括BiDz传感器,用于区分6临床相关的NTM物种(脓肿分枝杆菌,鸟分枝杆菌,胞内分枝杆菌,偶发分枝杆菌,堪萨斯分枝杆菌和结核分枝戈登)和结核杆菌

结果显示,使用荧光BiDz-NTM ST测定,研究人员成功鉴定了38临床分离株的种类。此外,用视觉BiDz传感器测试了一部分菌株,为肉眼观察NTM的物种分类提供了概念验证。

结论表明,BiDz-NTM ST试验是一种快速鉴定NTM物种的新平台。该方法具有高度特异性,并且比现有工具快得多,并且很容易适用于医院或临床实验室的现场诊断实验室。

原始出处:

Hillary N. Wood, Ashelyn E. Sidders, Lauren E. Brumsey, Species Typing of Nontuberculous Mycobacteria by Use of Deoxyribozyme Sensors

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    2019-02-09 mjldent
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    2019-02-07 lietome15

    认真学习,不断进步,把经验分享给同好。点赞了!

    0

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    2019-02-07 一天没事干

    很好的学习机会

    0

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中国科学院微生物研究所刘翠华研究团队致力于研究Mtb等重要病原菌与宿主相互作用的分子机制,发现了Mtb通过调控宿主细胞功能促进对宿主固有免疫逃逸及肺癌发生发展的新机制,并揭示了病原菌与宿主间相互博弈的动态过程及分子机制,为抗结核药物研发提供了新思路和特异靶点。

Science:重磅:南开大学饶子和院士团队破解结核分枝杆菌能量代谢奥秘,助力抗结核新药研发

美国东部时间10月25日下午,该成果论文以研究长文的形式在线发表于国际顶级学术期刊《科学》(Science)上。北京时间26日下午,饶子和院士在南开大学省身楼举办的发布会上介绍了这一重大科学进展。

Eur Respir J:解释结核分枝杆菌突变与耐药表型关系的标准化方法!

这项研究提供了一种标准化和全面的解释突变的方法,以作为结核杆菌耐药表型的预测因子。这些数据为分子诊断和新一代测序提供了临床解释,并可能实现耐药结核患者有效的个体化治疗。

JCLA:检测结核分枝杆菌RT-LAMP和LAMP法的评估

目前用于检测结核分枝杆菌(Mtb)的方法在临床上并不是最优化的。其中,标准培养方法(SCM)速度慢,成本昂贵且可能不可靠,而环介导的等温扩增(LAMP)不能区分活Mtb。 该研究比较了用于检测Mtb的几种方法,包括逆转录(RT)-LAMP,LAMP和SCM。对9种的结核分枝杆菌(H37Rv,胞内分枝杆菌,海分枝杆菌,堪萨斯分枝杆菌,鸟分枝杆菌,M.苦参,耻垢分枝杆菌,偶发分枝杆菌,和龟分枝杆菌)