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J Neuroinflammation：研究揭示miR-129-5p改善缺血再灌注后的神经炎症和血-脊髓屏障损伤的机制

2017-11-05 MedSci MedSci原创

miR-129-5p缺血再灌注
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缺血-再灌注（IR）影响微小RNA（miR）的表达并可导致明显炎症的发生。近期研究报道了肿瘤抑制因子miR-129-5p在脑IR中的多种作用，但其在脊髓中的功能尚不清楚。在此，我们研究了脊髓IR后miR-129-5p的作用，特别是调节高迁移率族蛋白B1（HMGB1）和Toll样受体（TLR）-3途径。通过主动脉弓阻塞5分钟诱导缺血。通过RT-PCR，蛋白质印迹和荧光素酶测定来阐明miR-129-5

缺血-再灌注（IR）影响微小RNA（miR）的表达并可导致明显炎症的发生。近期研究报道了肿瘤抑制因子miR-129-5p在脑IR中的多种作用，但其在脊髓中的功能尚不清楚。在此，我们研究了脊髓IR后miR-129-5p的作用，特别是调节高迁移率族蛋白B1（HMGB1）和Toll样受体（TLR）-3途径。
通过主动脉弓阻塞5分钟诱导缺血。通过RT-PCR，蛋白质印迹和荧光素酶测定来阐明miR-129-5p和HMGB1之间的关系。通过双重免疫荧光来确定HMGB1的细胞分布。用合成miRs、rHMGB1和TLR3激动剂Poly（I：C）评估miR-129-5p对HMGB1、TLR3和下游细胞因子表达的影响。通过测量伊文思蓝（EB）染料外渗和水含量来检查血-脊髓屏障（BSCB）的渗透性。


瞬时miR-129-5p和HMGB1表达谱和荧光素酶测定结果表明miR-129-5p靶向HMGB1。与Sham组比较，IR组HMGB1免疫反应性较高，主要分布于神经元和小胶质细胞。鞘内注射miR-129-5p模拟物可显著降低术后48h HMGB1、TLR3、白细胞介素（IL）-1β和肿瘤坏死因子（TNF）-α的水平及双标记细胞计数，而rHMGB1和Poly （I：C）则可逆转这些影响。基于增加的巴索鼠标量表评分显示注射miR-129-5p模拟物保存了运动功能并防止BSCB外泄，还可减少EB外渗及水含量，而注射rHMGB1和Poly（I：C）则会加重这些损伤。

该研究结果表明，miR-129-5p水平的升高通过抑制HMGB1和TLR3相关细胞因子来改善炎症诱导的神经元和BCSB损伤，从而保护机体免于IR的损伤。

原始出处：

Xiao-Qian Li, Feng-Shou Chen, et al., Elevated microRNA-129-5p level ameliorates neuroinflammation and blood-spinal cord barrier damage after ischemia-reperfusion by inhibiting HMGB1 and the TLR3-cytokine pathway. J Neuroinflammation. 2017; 14: 205. doi:  10.1186/s12974-017-0977-4

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    2018-01-24 smallant2002

    #miR#

    0

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    2018-03-01 liye789132262

    #神经炎#

    0

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    2017-12-11 lxg951

    #LAM#

    0

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    2017-11-07 ms3046638856685384

    #损伤#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1930534, encodeId=7b4e19305342b, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Wed Jan 24 21:58:00 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1717503, encodeId=aaf51e17503c6, content=<a href='/topic/show?id=1a47e436211' target=_blank style='color:#2F92EE;'>#神经炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74362, encryptionId=1a47e436211, topicName=神经炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=662f32423113, createdName=liye789132262, createdTime=Thu Mar 01 22:58:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057616, encodeId=a900205e616f5, content=<a href='/topic/show?id=c02b106e29a' target=_blank style='color:#2F92EE;'>#LAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10672, encryptionId=c02b106e29a, topicName=LAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Mon Dec 11 01:58:00 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397377, encodeId=26bd139e377ef, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Tue Nov 07 11:58:00 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454828, encodeId=25e914548282b, content=<a href='/topic/show?id=ca5f12e51d4' target=_blank style='color:#2F92EE;'>#NFL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12751, encryptionId=ca5f12e51d4, topicName=NFL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=90805606164, createdName=xiaoyeshuang, createdTime=Tue Nov 07 11:58:00 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545553, encodeId=45a915455530a, content=<a href='/topic/show?id=7c4c984645' target=_blank style='color:#2F92EE;'>#inflammation#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9846, encryptionId=7c4c984645, topicName=inflammation)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffd513772211, createdName=ms6980045490879608, createdTime=Tue Nov 07 11:58:00 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259005, encodeId=d88d2590054d, content=很好的文章.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Mon Nov 06 00:13:14 CST 2017, time=2017-11-06, status=1, ipAttribution=)]
    2017-11-07 xiaoyeshuang

    #NFL#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1930534, encodeId=7b4e19305342b, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Wed Jan 24 21:58:00 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1717503, encodeId=aaf51e17503c6, content=<a href='/topic/show?id=1a47e436211' target=_blank style='color:#2F92EE;'>#神经炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74362, encryptionId=1a47e436211, topicName=神经炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=662f32423113, createdName=liye789132262, createdTime=Thu Mar 01 22:58:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057616, encodeId=a900205e616f5, content=<a href='/topic/show?id=c02b106e29a' target=_blank style='color:#2F92EE;'>#LAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10672, encryptionId=c02b106e29a, topicName=LAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Mon Dec 11 01:58:00 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397377, encodeId=26bd139e377ef, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Tue Nov 07 11:58:00 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454828, encodeId=25e914548282b, content=<a href='/topic/show?id=ca5f12e51d4' target=_blank style='color:#2F92EE;'>#NFL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12751, encryptionId=ca5f12e51d4, topicName=NFL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=90805606164, createdName=xiaoyeshuang, createdTime=Tue Nov 07 11:58:00 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545553, encodeId=45a915455530a, content=<a href='/topic/show?id=7c4c984645' target=_blank style='color:#2F92EE;'>#inflammation#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9846, encryptionId=7c4c984645, topicName=inflammation)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffd513772211, createdName=ms6980045490879608, createdTime=Tue Nov 07 11:58:00 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259005, encodeId=d88d2590054d, content=很好的文章.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Mon Nov 06 00:13:14 CST 2017, time=2017-11-06, status=1, ipAttribution=)]
    2017-11-07 ms6980045490879608

    #inflammation#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1930534, encodeId=7b4e19305342b, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Wed Jan 24 21:58:00 CST 2018, time=2018-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1717503, encodeId=aaf51e17503c6, content=<a href='/topic/show?id=1a47e436211' target=_blank style='color:#2F92EE;'>#神经炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74362, encryptionId=1a47e436211, topicName=神经炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=662f32423113, createdName=liye789132262, createdTime=Thu Mar 01 22:58:00 CST 2018, time=2018-03-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2057616, encodeId=a900205e616f5, content=<a href='/topic/show?id=c02b106e29a' target=_blank style='color:#2F92EE;'>#LAM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10672, encryptionId=c02b106e29a, topicName=LAM)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=04ce158, createdName=lxg951, createdTime=Mon Dec 11 01:58:00 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397377, encodeId=26bd139e377ef, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Tue Nov 07 11:58:00 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454828, encodeId=25e914548282b, content=<a href='/topic/show?id=ca5f12e51d4' target=_blank style='color:#2F92EE;'>#NFL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12751, encryptionId=ca5f12e51d4, topicName=NFL)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=90805606164, createdName=xiaoyeshuang, createdTime=Tue Nov 07 11:58:00 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1545553, encodeId=45a915455530a, content=<a href='/topic/show?id=7c4c984645' target=_blank style='color:#2F92EE;'>#inflammation#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9846, encryptionId=7c4c984645, topicName=inflammation)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ffd513772211, createdName=ms6980045490879608, createdTime=Tue Nov 07 11:58:00 CST 2017, time=2017-11-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=259005, encodeId=d88d2590054d, content=很好的文章.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160914/IMG57D82E721DB581755.jpg, createdBy=4fc81933929, createdName=明天会更好！, createdTime=Mon Nov 06 00:13:14 CST 2017, time=2017-11-06, status=1, ipAttribution=)]
    2017-11-06 明天会更好！

    很好的文章.谢谢分享

    0