Ann Rheum Dis:孕期类风湿性关节炎患者所生子女的DNA甲基化有改变

2019-05-30 xiangting MedSci原创

RA患者所生子女与一般人群子女在147个CpGs上存在DNA甲基化差异。

这项研究的主要目的是确定类风湿性关节炎(RA)母亲所生子女的DNA甲基化特征是否与一般人群子女的DNA甲基化不同。此外,还要确定甲基化差异是否与妊娠期母体RA疾病活动性或用药相关。

在这项研究中,使用Infinium Illumina人类甲基化450K BeadChip,对RA患者所生子女的80份血样(平均年龄=6.8岁),在胞嘧啶-磷酸-鸟嘌呤(CpG)位点检测了全基因组DNA甲基化。使用来自基于群体Generation R研究的354名儿童血样作为对照(平均年龄=6.0岁)。进行线性混合模型以分析组间的差异甲基化,并校正相关混杂因子。

RA母亲所生子女的血液样本与对照血样共有147个差异甲基化CpGs。5个最显著的相关CpGs是cg06642177、cg08867893、cg06778273、cg07786668和cg20116574。甲基化差异与孕期母体RA疾病活动性或用药无关。

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    2019-06-01 lmm397
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