NEJM:默克尔细胞癌-病例报道

2019-12-05 xing.T MedSci原创

默克尔细胞癌是一种侵袭性皮肤神经内分泌肿瘤,与多瘤病毒感染、免疫抑制、高龄和日晒有关。通常在患者阳光照射区皮肤出现红色或粉红色扩大结节。

患者为一名62岁的妇女,为评估其右手迅速增大的结节而到皮肤科就诊,该结节已出现1个月以上。她报告该区域没有创伤,也没有全身症状,例如发热、盗汗和体重减轻。

体格检查发现手指根部上方无痛性红色结节状结节(如图A所示)。没有发现其他病变,也没有发现淋巴结肿大。通过穿刺活检获得的标本进行分析后发现真皮中出现了结节性浸润(如图B所示),并诊断为默克尔细胞癌。



默克尔细胞癌是一种侵袭性皮肤神经内分泌肿瘤,与多瘤病毒感染免疫抑制、高龄和日晒有关。通常在患者阳光照射区皮肤出现红色或粉红色扩大结节。

该患者进行了截肢,由于从前哨淋巴结获得的活检标本为恶性细胞阳性,因此进行了腋窝淋巴结清扫术。在5个月的随访中没有发现复发的迹象。 

原始出处:

Pedro J. Gomez-Arias,et al.Merkel-Cell Carcinoma.N Engl J Med 2019;https://www.nejm.org/doi/full/10.1056/NEJMicm1907250

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    2019-12-05 LaserDermatol

    截指吧

    0

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    2019-12-05 旺医

    顶刊就是顶刊,谢谢梅斯带来这么高水平的研究报道,我们科里同事经常看梅斯,分享梅斯上的信息

    0

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