盘点:2018年6月2日Lancet研究精选

2018-06-01 zhangfan MedSci原创

2018年6月2日Lancet研究精选



【1】封面文章--Guselkumab治疗银屑病性关节炎效果显著


白介素23p19亚基单抗Guselkumab是中重度银屑病的有效治疗药物, 近日研究人员公布了其治疗银屑病性关节炎的疗效和安全性数据。

活动性或斑块性银屑病患者参与研究,随机接受治疗或安慰剂,主要终点是24周满足ACR20体征和症状改善患者比例。149人参与研究,100人接受药物治疗,其中58%的满足ACR20改善指标,而安慰剂组仅18%的患者治疗后改善。组间不良事件及严重程度相近。

【2】节镜下髋关节手术治疗髋臼撞击综合征效果优于保守治疗


髋臼撞击综合征是青年人髋关节疼痛的重要原因,其治疗手段包括关节镜下髋关节手术,如髋关节整形或保守物理治疗。近日研究人员就不同疗法的治疗效果差异进行了考察。

16岁以上,有髋关节疼痛、满足X线特征的非骨关节炎患者参与研究,随机接受髋关节镜或保守治疗,主要终点为与臀部有关的生活质量评估。171人接受髋关节镜治疗,177人接受保守治疗。12个月后髋关节镜组生活质量评分为58.8分vs对照组为49.7分。髋关节镜组报告了147起不良事件vs保守治疗组102起,主要为肌痛。

【3】195个国家26年医疗质量排行榜


近期研究人员就1990-2016年间195个国家和地区的医疗保健服务和质量指数(HAQ指数)进行了评估。

1990-2016年间, 195个国家和地区中有186个国家和地区的HAQ指数得分显着提高,中国,马尔代夫,秘鲁和泰国等几个国家的增长最为明显,但2016年HAQ指数的发展出现区域分化,不平等现象日益严重,尤其是中国、印度等发展中国家中区域分化尤为明显。研究发现医疗保健服务在疫苗、可预防疾病、传染病和母婴健康以及需要复杂病例管理的疾病(例如癫痫糖尿病和慢性肾病疾病)等方面获得的收益较大,但癌症和一些非传染性疾病的收益较低,特别是非传染性疾病医疗保健服务方面的投资不足。政府支出占医疗总支出的比例与2016年HAQ指数表现呈正相关,而卫生发展援助则呈现出负相关,这些卫生系统措施及其与HAQ指数的关系出现了相当大的异质性,尤其是在中高等SDI国家。

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    2018-08-12 howi
  2. [GetPortalCommentsPageByObjectIdResponse(id=1829656, encodeId=0c971829656d4, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Aug 12 17:54:00 CST 2018, time=2018-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320876, encodeId=be103208e698, content=好少, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLS3nbTc0lzBwDxSVnm5KA9vNmsZrjTSvKlld6teMf4RG4ZmZWRvC80GB7zl4TSib3BAoZgcCYpzxQ/132, createdBy=02681961038, createdName=若轩, createdTime=Sat Jun 02 16:46:37 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320607, encodeId=a87c32060e7a, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Fri Jun 01 18:34:09 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320565, encodeId=f5b932056565, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Fri Jun 01 15:02:41 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
    2018-06-02 若轩

    好少

    0

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    2018-06-01 131****1460

    学习了受益匪浅

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1829656, encodeId=0c971829656d4, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun Aug 12 17:54:00 CST 2018, time=2018-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320876, encodeId=be103208e698, content=好少, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLS3nbTc0lzBwDxSVnm5KA9vNmsZrjTSvKlld6teMf4RG4ZmZWRvC80GB7zl4TSib3BAoZgcCYpzxQ/132, createdBy=02681961038, createdName=若轩, createdTime=Sat Jun 02 16:46:37 CST 2018, time=2018-06-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320607, encodeId=a87c32060e7a, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Fri Jun 01 18:34:09 CST 2018, time=2018-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=320565, encodeId=f5b932056565, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Fri Jun 01 15:02:41 CST 2018, time=2018-06-01, status=1, ipAttribution=)]
    2018-06-01 139****5926

    好好文章学习了

    0

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