EUR J CANCER:转移性皮肤顶浆分泌腺癌对PD-1抗体pembrolizumab的响应

2017-12-20 MedSci MedSci原创

皮肤顶浆分泌腺癌(Cutaneous apocrine adenocarcinoma)是一种罕见的汗腺癌,其发病部位多处于上躯干和头/颈部区域。对于该疾病,预测患者生存期的最重要的评判标准即为阳性淋巴结状态。而对于转移性皮肤顶浆分泌腺癌患者,目前尚无有效的治疗方法,因此患者5年总生存率低于10%。

皮肤顶浆分泌腺癌(Cutaneous apocrine adenocarcinoma)是一种罕见的汗腺癌,其发病部位多处于上躯干和头/颈部区域。对于该疾病,预测患者生存期的最重要的评判标准即为阳性淋巴结状态。而对于转移性皮肤顶浆分泌腺癌患者,目前尚无有效的治疗方法,因此患者5年总生存率低于10%

近日,奥地利Medical University of Graz的学者公布了一项临床案例,该83岁的皮肤顶浆分泌腺癌患者已在3个月前接受了肿瘤和淋巴结切除手术,但经CT扫描发现,其肺部和纵隔淋巴结处存在转移性癌症组织。鉴于目前尚无更为有效的治疗方法,同时考虑到PD-1抗体对多种实体瘤的治疗作用,医生决定采用PD-1抗体pembrolizumab对其进行治疗,其剂量为每3周静脉注射pembrolizumab2 mg/kg 体重)。结果显示,在治疗过程中,患者对pembrolizumab耐受性良好,无明显不良反应。治疗4个周期(12周)后,CT扫描发现患者病情稳定(依照iRECIST标准);治疗8个周期(24周)后,患者病情部分缓解;治疗16个周期(48周)后,患者病情持续缓解,且淋巴结缩小为正常大小。

因此该案例对pembrolizumab用于治疗罕见的汗腺癌提供了指导。 

原始出处:

Rogatsch, Max, et al. "Metastatic cutaneous apocrine adenocarcinoma responsive to the programmed cell death protein 1 inhibitor pembrolizumab." European Journal of Cancer 2017. doi.org/10.1016/j.ejca

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    2018-07-08 仁医06
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    2018-05-11 gwc392
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    2018-06-28 chendoc242
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