Gastroenterology:炎症性肠病相关环境因素研究

2019-04-24 MedSci MedSci原创

研究发现不同环境因素与IBD风险存在不同程度的关联,仍需要对最近诊断为IBD患者的样本进行高质量前瞻性研究,以确定这些因素是IBD的原因还是结果

炎症性肠病(IBD)的发生与多种环境因素有关,近日研究人员开展荟萃分析总结现有的流行病学证据并评估其可信度。

研究人员系统地鉴定和评估了观察研究,这些研究考察了环境因素与IBD(克罗恩病[CD]或溃疡性结肠炎[UC])风险的相关性。对于每个荟萃分析,我们考虑了随机效应估计、95%可信区间、异质性估计和小研究效应,并根据预先规定的标准对证据进行分级。证据质量评估使用AMSTAR 2。

研究人员对71个与生活方式和卫生、手术、药物接触、饮食、微生物和疫苗接种有关的环境因素进行了53次荟萃分析,并对183项评估进行了检验。我们确定了9个增加IBD风险的因素:吸烟(CD)、城市生活(CD和IBD)、阑尾切除术(CD)、扁桃体切除术(CD)、抗生素暴露(IBD)、口服避孕药(IBD)、软饮料消费(UC)、维生素D缺乏(IBD)和非幽门螺杆菌样肠肝螺旋杆菌(IBD)。我们确定了7个降低IBD风险的因素:体力活动(CD)、母乳喂养(IBD)、亲子同床(CD)、喝茶(UC)、高水平叶酸(IBD)、高水平维生素D(CD)、幽门螺杆菌感染(CD、UC和IBD)。所有这些流行病学证据都具有高到中等强度的,研究人员确定了另外11个与风险增加相关的因素和16个与风险降低相关的因素,但可信度较低。

研究发现不同环境因素与IBD风险存在不同程度的关联,仍需要对最近诊断为IBD患者的样本进行高质量前瞻性研究,以确定这些因素是IBD的原因还是结果。

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    2020-02-05 许安
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