J Hepatol:年轻男性饮酒后患无穷 生命后期严重肝病风险增加!

2018-04-17 林巧楠 环球医学网

发表于《J Hepatol》上的一项研究,表明了青春期晚期饮酒与后期严重肝病风险的增加相关。

发表于《J Hepatol》上的一项研究,表明了青春期晚期饮酒与后期严重肝病风险的增加相关。

背景&目的:大量饮酒与严重肝病风险增加相关。目前指南指出男性每天摄入30克酒精是安全的。研究者旨在调查年轻时饮酒与后期发展为严重肝病的相关性。

方法:研究者使用了1969至1970年间瑞典43296名男性(18~20岁)募兵兵役时的饮酒数据。结局定义为截至2009年时来自系统国家注册库临床事件的严重肝病诊断。采用Cox回归模型校正了体质指数、吸烟、麻醉毒品的使用、认知能力和心血管功能。

结果:在平均随访37.8年内,383名男性出现严重肝病。饮酒与严重肝病风险的增加存在剂量-效应模式上相关性(每日增加1 g的校正危险比为1.02;95% CI:1.01~1.02)。未发现阈值效应。重要的是,一种明显的趋势表明即使每日摄入低于30 g酒精的男性患严重肝病的风险也会增加。

结论:年轻男性饮酒与严重肝病风险增加相关,长达其后的39年。风险是剂量依赖性的,没有阈值效应的迹象。目前关于男性安全饮酒的指导方针可能需要修改。

原始出处:
Hagstrm H, Hemmingsson T, Discacciati A, et al.Alcohol consumption in late adolescence is associated with an increased risk of severe liver disease later in life.J Hepatol. 2018 Mar;68(3):505-510. doi: 10.1016/j.jhep.2017.11.019. Epub 2018 Jan 22.

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    2018-04-19 gwc384
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    2018-04-18 sunfeifeiyang

    0

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    2018-04-17 wuqianhong99

    控酒也要放到纪事日程!

    0

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    2018-04-17 神功盖世

    0

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    2018-04-17 1e0f8808m18(暂无匿称)

    饮酒要适度.否则后患无穷.

    0

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年轻男性,突然出现精神异常,何病?

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