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GelMA/壳聚糖纳米复合水凝胶可有效用于血管生长因子的载送

2017-12-06 MedSci MedSci原创

水凝胶血管生长因子
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细胞微环境在改善组织工程的细胞响应和功能方面起关键作用。仿生ECM及能释放生长因子的支架是组织工程应用的理想支架。明胶甲基丙烯酰基（GelMA）水凝胶是一种具有可调谐特性的可见光交联生物材料，已广泛应用于组织工程。有研究人员提出，在GelMA中掺入微/纳米载体可以提供生长因子的持续释放。具体而言，壳聚糖纳米颗粒由于其生物相容性，易于合成的方法以及防止生物分子降解而可用于生长因子递送。在这项研究中，

细胞微环境在改善组织工程的细胞响应和功能方面起关键作用。仿生ECM及能释放生长因子的支架是组织工程应用的理想支架。

明胶甲基丙烯酰基（GelMA）水凝胶是一种具有可调谐特性的可见光交联生物材料，已广泛应用于组织工程。有研究人员提出，在GelMA中掺入微/纳米载体可以提供生长因子的持续释放。具体而言，壳聚糖纳米颗粒由于其生物相容性，易于合成的方法以及防止生物分子降解而可用于生长因子递送。

在这项研究中，研究人员合成了GelMA /壳聚糖纳米粒子复合水凝胶以载送血管生长因子（bFGF）。通过光聚合制备水凝胶，并对其化学和物理性质进行表征。此外，评估其降解和膨胀特性。最后，评估了纳米粒子的大小，研究了水凝胶bFGF的释放及其对成纤维细胞活力的影响。

结果表明，GelMA /壳聚糖纳米粒子由于其生物相容性结构可显著促进细胞增殖，并提供bFGF持续释放的特征。该水凝胶支架可有效用于各种生物应用，特别是血管生成中有效递送bFGF。

原始出处：

Modaresifar K, Hadjizadeh A, Niknejad H. Design and fabrication of GelMA/chitosan nanoparticles composite hydrogel for angiogenic growth factor delivery. Artif Cells Nanomed Biotechnol. 2017 Oct 24:1-10. doi: 10.1080/21691401.2017.1392970.

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    2017-12-08 tastas

    #水凝胶#

    0

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    2017-12-08 lishizhe

    #凝胶#

    0

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    2017-12-08 12499e01m50暂无昵称

    #生长因子#

    0

  4. 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createdBy=92191944782, createdName=thlabcde, createdTime=Thu Dec 07 20:02:15 CST 2017, time=2017-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267463, encodeId=852c26e4638a, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Dec 07 07:19:14 CST 2017, time=2017-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267441, encodeId=dcca26e4410f, content=可以理解为持续止血吗?, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Wed Dec 06 23:05:19 CST 2017, time=2017-12-06, status=1, ipAttribution=)]
    2017-12-08 dlwang_26703132

    #壳聚糖#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1308006, encodeId=62d213080067f, content=<a href='/topic/show?id=edd364149bc' target=_blank style='color:#2F92EE;'>#水凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64149, encryptionId=edd364149bc, topicName=水凝胶)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=47c5349, createdName=tastas, createdTime=Fri Dec 08 12:56:00 CST 2017, time=2017-12-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460942, encodeId=0392146094288, content=<a href='/topic/show?id=de4331310a4' target=_blank style='color:#2F92EE;'>#凝胶#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31310, encryptionId=de4331310a4, topicName=凝胶)], attachment=null, authenticateStatus=null, createdAvatar=null, 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createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJNCjP5GJqqBZFlbk1Dm8cXyP7gpY57Ut698B6phuTyicrxr4kcWYkhhCCeAmco6PFOMa0JSribUP9A/0, createdBy=cfcb2174142, createdName=wangvase, createdTime=Thu Dec 07 06:56:55 CST 2017, time=2017-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267431, encodeId=0dca26e431f8, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, createdName=chunjianf, createdTime=Thu Dec 07 06:38:27 CST 2017, time=2017-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267362, encodeId=2e6e26e3625f, content=学了......., beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Wed Dec 06 23:05:19 CST 2017, time=2017-12-06, status=1, ipAttribution=)]
    2017-12-07 131****2916

    不错的文章值得推荐

    0

  6. 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createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJNCjP5GJqqBZFlbk1Dm8cXyP7gpY57Ut698B6phuTyicrxr4kcWYkhhCCeAmco6PFOMa0JSribUP9A/0, createdBy=cfcb2174142, createdName=wangvase, createdTime=Thu Dec 07 06:56:55 CST 2017, time=2017-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267431, encodeId=0dca26e431f8, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, createdName=chunjianf, createdTime=Thu Dec 07 06:38:27 CST 2017, time=2017-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267362, encodeId=2e6e26e3625f, content=学了......., beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Wed Dec 06 23:05:19 CST 2017, time=2017-12-06, status=1, ipAttribution=)]
    2017-12-07 thlabcde

    好资料学习了!

    0

  7. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Wed Dec 06 23:05:19 CST 2017, time=2017-12-06, status=1, ipAttribution=)]
    2017-12-07 明月清辉

    谢谢分享.学习了

    0

  8. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Wed Dec 06 23:05:19 CST 2017, time=2017-12-06, status=1, ipAttribution=)]
    2017-12-07 wangvase

    可以理解为持续止血吗?

    0

  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJNCjP5GJqqBZFlbk1Dm8cXyP7gpY57Ut698B6phuTyicrxr4kcWYkhhCCeAmco6PFOMa0JSribUP9A/0, createdBy=cfcb2174142, createdName=wangvase, createdTime=Thu Dec 07 06:56:55 CST 2017, time=2017-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267431, encodeId=0dca26e431f8, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfNLvzZhgPxRk75KAEKrLGic0S0IvH1aNynsEFQWiaNKdtzvtwj2kafCoPg2icYVbrfBCFiaS74X1uEiaaTTY1H9Xyem/0, createdBy=cec11614828, createdName=chunjianf, createdTime=Thu Dec 07 06:38:27 CST 2017, time=2017-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=267362, encodeId=2e6e26e3625f, content=学了......., beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Wed Dec 06 23:05:19 CST 2017, time=2017-12-06, status=1, ipAttribution=)]
    2017-12-07 chunjianf

    学习了.谢谢分享

    0

  10. 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replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Neru1qt53a14aACuSzg3TZhkTcsPYVibyHibhTZ5L4k9qIBWiaej4lgomIsGptf8N16E4mTuIq2DVdJXjPjmwZKrLib/0, createdBy=5a0f2055853, createdName=135****7952平儿, createdTime=Wed Dec 06 23:05:19 CST 2017, time=2017-12-06, status=1, ipAttribution=)]
    2017-12-06 135****7952平儿

    学了.......

    0

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骨膜在骨组织再生过程中在新矿化、血管化和屏障中起着举足轻重的作用。然而，许多人造骨膜只关注骨膜的屏障功能，缺乏对其成骨和血管生成功能的研究。在这项研究中，研究人员研发了一种新型无机强化明胶水凝胶膜，通过无机和有机共交联双网络作为人造骨膜，增强骨重建中血管生成和骨生成。将光交联明胶衍生物（GelMA）化学修饰的介孔生物活性玻璃纳米粒子（MBGNs）进一步掺入GelMA中以制备有机/无机共交联水凝胶膜

Nat Cell Biol：利用人工合成水凝胶投递细胞以修复肠道损伤

研究人员将人工合成聚合材料的水凝胶与类器官的复杂肠组织（由人类多能干细胞形成）结合在一起，开发出控制这些组织生长，以及利用它们治疗消化系统损伤的新技术。消化系统损伤通常由炎性肠道疾病(IBD)引起，这一技术使他们向着成功又迈出重要一步。

J Colloid Interface Sci：混合水凝胶不仅可载药还可抗菌

水凝胶是一种很有应用前景的3D材料，越来越多的研究发现其可作为药物和细胞载体及递送进行应用。本研究中，我们报告了一个可注射的胶体水凝胶，直接由氧化石墨烯（GO）和热敏纳米凝胶（tNG）制备。羧基和氧乙基之间的pH依赖性氢键相互作用可使得GO和纳米凝胶之间形成可逆组装。水凝胶是可塑的，可以成型为不同的形状，随着pH和温度的变化其机械强度可调。实验研究结果显示，该混合水凝胶具有较高的抗菌活性，且作为支

Bone Res：仿生双相CAN-PAC水凝胶可用于软骨缺损修复

基于仿生支架的软骨组织工程已成为修复软骨缺陷的一个重要方法。在本研究中，研究人员通过热反应快速交联方法，利用两层之间的密度差制备了用于软骨缺损（OCD）再生的双相CAN-PAC水凝胶。上水凝胶通过CSMA和NIPAm交联，下水凝胶由PECDA，AAm和PEGDA组成。两层之间的界面首先通过葡萄糖酸钙和藻酸盐的物理交联连接，然后在其它组分中进行碳-碳双键的化学交联。上下水凝胶的孔径分别为〜187.4

Sci Rep：新型水凝胶可有效输送干细胞并增强其活力

支架种子细胞存活率低仍是干细胞骨再生所面临的一大挑战。本研究旨在利用丝凝胶将更多的干细胞移植到骨缺损区，并增强这些细胞植入后的生存能力。研究人员提取大鼠骨髓干细胞，并与丝素凝胶混合，凝胶前干细胞浓度为1.0 × 105/mL、1.0 × 106/mL及1.0 × 107/mL，将其逐滴加入到丝支架，并应用于大鼠颅骨缺损。细胞追踪实验观察细胞活力和功能的保存情况。结果表明，干细胞浓度为1.0 × 1