Clin Gastroenterology H: 小儿嗜酸性粒细胞性食管炎的发病率和患病率研究分析

2019-01-11 MedSci MedSci原创

嗜酸性粒细胞性食管炎(EoE)经常在儿童中发生,并被认为是一种罕见疾病,据报道患病率低于60例每10万人。为了确定EoE发病率是否近年来有变化,研究人员计算了5年内的发病率。

背景与目的
嗜酸性粒细胞性食管炎(EoE)经常在儿童中发生,并被认为是一种罕见疾病,据报道患病率低于60例每10万人。为了确定EoE发病率是否近年来有变化,研究人员计算了5年内的发病率。

方法
研究人员使用共识指南进行EoE的诊断,同时调查了2011年7月1日至2016年6月31日患者的病理学数据库的病理记录。本项研究共收集了10619名有食管活检结果的儿科患者的数据,并确定了食管嗜酸性粒细胞增多症的病例(EoE定义:在内窥镜活组织检查中,在高倍显微镜领域中有> 14个嗜酸性粒细胞)。EoE病例需要存在食管嗜酸性粒细胞增多,食管功能障碍的症状,以及没有可能引起食管嗜酸性粒细胞增多的共病症。根据2010年和2016年美国人口普查数据的平均儿科人口估计数,计算了每100000名儿童的EoE发病率和患病率值。

结果
研究人员确定了1281名符合食管嗜酸粒细胞增多标准的儿科患者。其中,1060名患者符合指南规定的EoE标准。在随访的5年期间,美国平均每年儿童EoE发病率为每10万名儿童中有24例。该研究第5年的患病率为每10万名儿童118例。

结论
本项基于美国儿童的研究中,研究人员发现儿科EoE的发病率和患病率高于此前报道的水平。这可能是由于该地区EoE风险因素的突出,因此需要在未来增加对EoE诊断和治疗的重视。

原始出处:

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  5. 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time=2019-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437393, encodeId=d63e143e39305, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Jan 13 09:55:00 CST 2019, time=2019-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462522, encodeId=6743146252238, content=<a href='/topic/show?id=d627101081d8' target=_blank style='color:#2F92EE;'>#食管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101081, encryptionId=d627101081d8, topicName=食管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8756488272, createdName=天堂的云, createdTime=Sun Jan 13 09:55:00 CST 2019, time=2019-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493159, encodeId=9052149315978, content=<a href='/topic/show?id=48524024105' target=_blank style='color:#2F92EE;'>#嗜酸性粒细胞性食管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40241, encryptionId=48524024105, topicName=嗜酸性粒细胞性食管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37a38986122, createdName=tidiq, createdTime=Sun Jan 13 09:55:00 CST 2019, time=2019-01-13, status=1, ipAttribution=)]
    2019-11-09 许安
  6. 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  7. 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encryptionId=9a1c289680, topicName=AST)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9831894722, createdName=ms24272190615788285182, createdTime=Tue Jan 15 21:55:00 CST 2019, time=2019-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072423, encodeId=e81e20e24230a, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sat Nov 09 16:55:00 CST 2019, time=2019-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1250598, encodeId=35911250598cd, content=<a href='/topic/show?id=7d6f52988e1' target=_blank style='color:#2F92EE;'>#患病率#</a>, beContent=null, objectType=article, 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time=2019-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437393, encodeId=d63e143e39305, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Jan 13 09:55:00 CST 2019, time=2019-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462522, encodeId=6743146252238, content=<a href='/topic/show?id=d627101081d8' target=_blank style='color:#2F92EE;'>#食管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101081, encryptionId=d627101081d8, topicName=食管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8756488272, createdName=天堂的云, createdTime=Sun Jan 13 09:55:00 CST 2019, time=2019-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493159, encodeId=9052149315978, content=<a href='/topic/show?id=48524024105' target=_blank style='color:#2F92EE;'>#嗜酸性粒细胞性食管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40241, encryptionId=48524024105, topicName=嗜酸性粒细胞性食管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37a38986122, createdName=tidiq, createdTime=Sun Jan 13 09:55:00 CST 2019, time=2019-01-13, status=1, ipAttribution=)]
  8. 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time=2019-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437393, encodeId=d63e143e39305, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Jan 13 09:55:00 CST 2019, time=2019-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462522, encodeId=6743146252238, content=<a href='/topic/show?id=d627101081d8' target=_blank style='color:#2F92EE;'>#食管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101081, encryptionId=d627101081d8, topicName=食管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8756488272, createdName=天堂的云, createdTime=Sun Jan 13 09:55:00 CST 2019, time=2019-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1493159, encodeId=9052149315978, content=<a href='/topic/show?id=48524024105' target=_blank style='color:#2F92EE;'>#嗜酸性粒细胞性食管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=40241, encryptionId=48524024105, topicName=嗜酸性粒细胞性食管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37a38986122, createdName=tidiq, createdTime=Sun Jan 13 09:55:00 CST 2019, time=2019-01-13, status=1, ipAttribution=)]
    2019-01-13 zhouqu_8
  9. 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  10. 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