Chest:慢性阻塞性肺病患者的慢性咳嗽

2020-02-19 不详 网络

慢性咳嗽在COPD患者中的作用和影响尚未在一般人群中描述。我们假设慢性合并咳嗽是COPD患者疾病严重程度的标志。我们从哥本哈根总人口研究的43271名成年人的嵌套队列中,鉴定出患有COPD和慢性咳嗽的人,并记录了呼吸系统症状,医疗保健利用,肺功能和血液中的炎症生物标志物。结果显示,在总人口的43271人中,有8181人(19%)患有慢性阻塞性肺病,其中796人(10%)患有慢性咳嗽。患有慢性阻塞性

慢性咳嗽在COPD患者中的作用和影响尚未在一般人群中描述。我们假设慢性合并咳嗽是COPD患者疾病严重程度的标志。

我们从哥本哈根总人口研究的43271名成年人的嵌套队列中,鉴定出患有COPD和慢性咳嗽的人,并记录了呼吸系统症状,医疗保健利用,肺功能和血液中的炎症生物标志物。

结果显示,在总人口的43271人中,有8181人(19%)患有慢性阻塞性肺病,其中796人(10%)患有慢性咳嗽。患有慢性阻塞性肺病和慢性咳嗽的人的莱斯特咳嗽问卷中位数总分为17.7(25-75%:16.0-18.9),对应于物理领域的5.9(5.3-6.3),心理领域的5.6(4.9-6.3),以及社交域的6.3(5.8-6.8)。在患有COPD的患者中,慢性咳嗽患者与无咳嗽患者相比,痰的产生频率更高(60%VS.8%),喘息(46%VS.14%),呼吸困难(66%VS.38%),胸痛/紧绷(9%VS.4%),夜间呼吸困难(8%VS.3%),最近10年的急性支气管炎/肺炎发作(45%VS.25%)以及过去12个月的全科医生就诊(53%VS.37 %)。此外,这些人的FEV1%预测值较低(81%VS.89%),FEV1 / FVC(0.64 VS.0.66),以及较高水平的高敏C反应蛋白,纤维蛋白原,白细胞,嗜中性粒细胞,嗜酸性粒细胞和IgE在血液中。

综上所述,该研究结果表明,从更多的呼吸道症状和医疗保健利用,较低的肺功能和血液中炎症增加的角度来看,慢性阻塞性肺病患者的合并性慢性咳嗽与更严重的疾病有关。

原始出处:

Landt E, Çolak Y, et al., Chronic cough in individuals with COPD: a population-based cohort study. Chest. 2020 Jan 24. pii: S0012-3692(20)30130-6. doi: 10.1016/j.chest.2019.12.038. 

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    2020-05-12 Smile2680
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    2021-01-28 amy0559
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    2020-04-06 tomyang96