PLos One:类风湿性关节炎患者16年间的有氧运动能力:与疾病活动性和心血管疾病危险因素的关系

2017-12-24 xiangting MedSci原创

高基线有氧运动能力与随访时有利的心血管危险因素指标相关。

这项研究的目的是分析从类风湿性关节炎(RA)发病16.2年以来的有氧能力的变化,及其与疾病活动性和心血管危险因素的关系。

1995-2002年间诊断为RA的25名患者(20f/ 5m)在疾病发作和平均16.2年后接受测试。测量参数包括:有氧能力的亚极量功率车测试,功能能力,自我效能,ESR,CRP和DAS28。在随访中,心血管危险因素评估为血脂,葡萄糖浓度,腰围,体质指数(BMI),身体成分,脉搏波分析和颈动脉内膜中层厚度。疾病发作时有氧运动能力[中位数(IQR)]为32.3(27.9-42.1)ml O 2/ kg×min,随访时为33.2(28.4-38.9)(p> 0.05)。基线有氧运动能力与以下随访值相关:BMI(r s = -.401,p = .047),腰围(r s = -.498,p = .011),周围脉压(r s = -.415,p = .039),自我效能(r s = .420,p = .037)和有氧能力(r s = .557,p = .004)。在针对基线有氧运动能力进行校正的多元回归模型中,基线和随时间的疾病活动性预测随访时的有氧运动能力(AUC DAS28,0-24个月; β = -.14,p = .004)。随访时,有氧能力与血糖水平呈负相关(r s = -.508,p = .016),BMI(r s=-.434,p = .030),体脂百分比(r s = -.419,p = .037),主动脉脉压(r s = -.405,p = .044),静息心率(r s = -.424,p = .034)和自我效能(r s = .464,p = .020)。

有氧能力维持了16年。高基线有氧运动能力与随访时有利的心血管危险因素指标相关。RA早期阶段疾病活动性较高可以预测16.2年后有氧能力较低。

原始出处:

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  5. 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  6. 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content=<a href='/topic/show?id=55a6100826cc' target=_blank style='color:#2F92EE;'>#风湿性关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100826, encryptionId=55a6100826cc, topicName=风湿性关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c237911872, createdName=ms1467340776200723, createdTime=Tue Dec 26 06:55:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1498344, encodeId=d327149834436, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Tue Dec 26 06:55:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1499989, encodeId=2f8c14999893b, content=<a href='/topic/show?id=a40c9421969' target=_blank style='color:#2F92EE;'>#运动能力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94219, encryptionId=a40c9421969, topicName=运动能力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=058e9400974, createdName=xzw116, createdTime=Tue Dec 26 06:55:00 CST 2017, time=2017-12-26, status=1, ipAttribution=)]
    2017-12-26 lmm397
  7. 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Clin oral invest:类风湿关节炎患者口腔健康相关生活质量取决于口腔健康状况

本研究的目的是评估类风湿关节炎(RA)患者的口腔健康相关生活质量(OHRQoL),取决于其与健康对照(HCs)的口腔健康状况。

Ann Rheum Dis:引入生物性DMARDs后类风湿性关节炎髋关节和膝关节置换的发生率

在1996年与GPC相比,RA患者中THR和TKR的发生率分别高3倍和14倍。

Ann Rheum Dis:患者特征影响RA生物性药物的选择,并使非TNFi生物制剂显得比TNFi生物制剂更有害

年龄较大和病情较重的RA患者更容易使用非TNFi bDMARDs,尤其是作为首个bDMARD。