JAHA:慢性肾脏病患者心衰危险因素分析!

2017-05-18 xing.T MedSci原创

该研究表明以胱抑素C为基础的eGFR与蛋白尿相比于以肌酐为基础的eGFR可以更好地预测心衰的风险。此外,贫血、胰岛素抵抗、炎症和血糖控制不佳是慢性肾脏病患者心衰发生的独立危险因素。

慢性肾脏病患者常发生心力衰竭。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员旨在分析了来自于慢性肾功能不全的队列研究(CRIC研究)的3557名参与者心力衰竭发生的危险因素。

研究人员使用血清肌酐、胱抑素C或两者,以及24小时尿白蛋白排泄得到的估计肾小球滤过率(eGFR)来评估肾功能。

在平均随访6.3年期间,452名参与者发生了心力衰竭。校正年龄、性别、种族和临床地域,以肌酐为基础的eGFR每降低1SD,其心衰风险比(95%可信区间)为1.67(1.49-1.89),以胱抑素C为基础的eGFR每降低1SD,其心衰风险比为2.43(2.10-2.80),蛋白尿对数每增加1SD,其心衰风险比为1.65(1.53-1.78),所有P<0.001。

当所有3项肾功能指标同时纳入模型时,以胱抑素C为基础的eGFR降低和蛋白尿对数升高仍然与心衰发生显著相关。将eGFR、蛋白尿与其他传统的心血管危险因素进行调整后,贫血(1.37,95%可信区间为1.09-1.72,P=0.006)、胰岛素抵抗(1.16,95%可信区间为1.04-1.28,P=0.006)、糖化血红蛋白(1.27,95%可信区间为1.14-1.41,P<0.001)、白细胞介素-6(1.15,95%可信区间为1.05-1.25,P=0.002)和肿瘤坏死因子-α(1.10,95%可信区间为1-1.21,P=0.05)均与心衰发生显著和直接相关。

该研究表明以胱抑素C为基础的eGFR与蛋白尿相比于以肌酐为基础的eGFR可以更好地预测心衰的风险。此外,贫血、胰岛素抵抗、炎症和血糖控制不佳是慢性肾脏病患者心衰发生的独立危险因素。

原始出处:

Jiang He, et al. Risk Factors for Heart Failure in Patients With Chronic Kidney Disease: The CRIC (Chronic Renal Insufficiency Cohort) Study.JAHA.2017. http://jaha.ahajournals.org/content/6/5/e005336

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    2017-06-18 jyzxjiangqin

    慢性肾病心衰的治疗。

    0

  2. 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    2017-06-07 jyzxjiangqin

    慢性肾脏病患者心衰危险。

    0

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    2017-06-06 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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GetPortalCommentsPageByObjectIdResponse(id=207422, encodeId=c89920e4221d, content=学习了,谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Tue Jun 06 21:56:23 CST 2017, time=2017-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202304, encodeId=f7f120230413, content=慢性肾脏病患者心衰危险因素。, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Thu May 25 07:19:52 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267444, encodeId=554e126e44404, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sat May 20 08:00:00 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616108, encodeId=73f11616108e4, content=<a href='/topic/show?id=9c95536521c' target=_blank style='color:#2F92EE;'>#慢性肾脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53652, encryptionId=9c95536521c, topicName=慢性肾脏)], attachment=null, 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level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Thu May 18 20:41:46 CST 2017, time=2017-05-18, status=1, ipAttribution=)]
    2017-05-25 jyzxjiangqin

    慢性肾脏病患者心衰危险因素。

    0

  5. 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    2017-05-20 zhaohui6731
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  7. 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07:19:52 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267444, encodeId=554e126e44404, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sat May 20 08:00:00 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616108, encodeId=73f11616108e4, content=<a href='/topic/show?id=9c95536521c' target=_blank style='color:#2F92EE;'>#慢性肾脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53652, encryptionId=9c95536521c, topicName=慢性肾脏)], attachment=null, 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authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Fri May 19 05:34:31 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199759, encodeId=d24f199e5947, content=学习啦谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Fri May 19 01:19:28 CST 2017, time=2017-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=199685, encodeId=2935199685a6, content=学习啦谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Thu May 18 20:41:46 CST 2017, time=2017-05-18, status=1, ipAttribution=)]
    2017-05-20 ylzr123

    好文,值得点赞!认真学习了,把经验应用于实践,为患者解除病痛。

    0

  8. 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07:19:52 CST 2017, time=2017-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267444, encodeId=554e126e44404, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Sat May 20 08:00:00 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1616108, encodeId=73f11616108e4, content=<a href='/topic/show?id=9c95536521c' target=_blank style='color:#2F92EE;'>#慢性肾脏#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53652, encryptionId=9c95536521c, topicName=慢性肾脏)], attachment=null, 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level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Thu May 18 20:41:46 CST 2017, time=2017-05-18, status=1, ipAttribution=)]
    2017-05-19 lou.minghong

    学。

    0

  9. 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level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLK1wzJZRTON4gxYUibhUyOypBwMibC4R7SsppicGhz5Ogoy0VVq4CWnqaD2Moeib8RWxI5lOiaVmnxpan/0, createdBy=c53f1730331, createdName=tanxingdoctor, createdTime=Thu May 18 20:41:46 CST 2017, time=2017-05-18, status=1, ipAttribution=)]
    2017-05-19 tanxingdoctor

    学习啦谢谢分享

    0

  10. 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    2017-05-18 tanxingdoctor

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