PLOS ONE：雄激素受体阳性的三阴乳腺癌：临床病理，预后和预测特征

2018-06-10 海北 MedSci原创

雄激素受体（AR）的过表达表征三阴性乳腺癌（TNBC）的独特分子亚群。 AR作为TNBC中预后/预测性生物标志物的作用是有争议的，但越来越多的证据表明该亚型可能对靶向AR的治疗剂有反应。

雄激素受体（AR）的过表达表征三阴性乳腺癌（TNBC）的独特分子亚群。 AR作为TNBC中预后/预测性生物标志物的作用是有争议的，但越来越多的证据表明该亚型可能对靶向AR的治疗剂有反应。

AR的评估尚未标准化，如何选择接受抗雄激素疗法的患者仍然存在争议。在最近的一项研究中，研究人员确定AR免疫反应性的适当阈值，以定义AR阳性（AR +）TNBC，描述了AR + TNBC的临床病理学特征，并讨论AR阳性作为TNBC中预后和预测标记的效用。

根据ASCO / CAP指南，研究人员处理了135例侵入性TNBC，对AR进行免疫染色。分析AR + TNBC的临床病理特征，并与AR阴性（AR-）TNBC比较。研究人员也统计评估了患者的年龄，肿瘤大小，肿瘤分级，淋巴结状态，增殖率，EGFR免疫阳性，CK5 / 6，Ki-67和无病生存率（DFS）。

研究人员将1％的切点确定为AR阳性的适当阈值。使用这个切点，135例TNBC中有41％是AR +。 AR + TNBC发生于老年女性，比AR-TNBC更大，平均增殖率更低，腋窝转移发生率更高。具有顶泌形态的TNBC中，76％是AR +。一部分AR + TNBC表达基础标志物（EGFR和CK5 / 6）。预测模型已创建。

因此，AR确定了TNBC的异质组。EGFR表达的额外评估使研究人员能够将TNBC分层为3个风险组，在DFS和治疗意义上存在显着差异：代表LAR分子亚型的低风险组（AR + EGFR-），具有最佳预后并且可能最大程度受益于抗雄激素治疗; 高风险组（AR-EGFR +），代表预后最差的基础分子亚型，并且可能从化疗方案中获益最多; 中等预后风险组（AR + EGFR +和AR-EGFR-）。需要进行前瞻性试验以进一步验证这种预后和预测分组。

原始出处：

Astvatsaturyan K et al. Androgen receptor positive triple negative breast cancer: Clinicopathologic, prognostic, and predictive features. PLOS ONE, 2018; DOI: 10.1371/journal.pone.0197827

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2019-04-14 mjldent

#激素受体阳性#

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2018-10-14 cmj8wellington

#临床病理#

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2018-06-16 119337457

#Plos one#

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2018-06-26 小小医森

和某大型骨干 v 巴基耶夫的现身说法有太多

51 0
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2018-06-25 小小医森

感谢分享.学习了

53 0
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2018-06-24 小小医森

哈哈哈哈哈哈哈哈好

60 0
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likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/06/05/ed2bf06fea1e697cb8fe1644bfcec307.jpg, createdBy=73971617491, createdName=小小医森, createdTime=Wed Jun 13 08:12:22 CST 2018, time=2018-06-13, status=1, ipAttribution=)]
2018-06-15 小小医森

感谢学习了

57 0
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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Thu Jun 14 06:32:02 CST 2018, time=2018-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323988, encodeId=d56132398843, content=哈哈哈哈哈哈哈哈好, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/06/05/ed2bf06fea1e697cb8fe1644bfcec307.jpg, createdBy=73971617491, createdName=小小医森, createdTime=Thu Jun 14 06:27:31 CST 2018, time=2018-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323786, encodeId=6aa4323e86d7, content=学习学习学习创新宣传促销, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/06/05/ed2bf06fea1e697cb8fe1644bfcec307.jpg, createdBy=73971617491, createdName=小小医森, createdTime=Wed Jun 13 08:12:22 CST 2018, time=2018-06-13, status=1, ipAttribution=)]
2018-06-14 jihuaijun1112

学习学习学习

45 0
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attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Thu Jun 14 06:32:02 CST 2018, time=2018-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323988, encodeId=d56132398843, content=哈哈哈哈哈哈哈哈好, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/06/05/ed2bf06fea1e697cb8fe1644bfcec307.jpg, createdBy=73971617491, createdName=小小医森, createdTime=Thu Jun 14 06:27:31 CST 2018, time=2018-06-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=323786, encodeId=6aa4323e86d7, content=学习学习学习创新宣传促销, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/06/05/ed2bf06fea1e697cb8fe1644bfcec307.jpg, createdBy=73971617491, createdName=小小医森, createdTime=Wed Jun 13 08:12:22 CST 2018, time=2018-06-13, status=1, ipAttribution=)]
2018-06-14 小小医森

哈哈哈哈哈哈哈哈好

25 0
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likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/06/05/ed2bf06fea1e697cb8fe1644bfcec307.jpg, createdBy=73971617491, createdName=小小医森, createdTime=Wed Jun 13 08:12:22 CST 2018, time=2018-06-13, status=1, ipAttribution=)]
2018-06-13 小小医森

学习学习学习创新宣传促销

29 0

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PLOS ONE：雄激素受体阳性的三阴乳腺癌：临床病理，预后和预测特征

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