JAMA Network Open:年轻癌症幸存者内分泌患病风险增高

2018-07-03 小闪 医学论坛网肿瘤

导语 青少年和年轻成年癌症幸存者的内分泌疾病风险比无癌人群高73%。


导语

青少年和年轻成年癌症幸存者的内分泌疾病风险比无癌人群高73%。

根据2018年6月29日在线发表于JAMA Network Open的一项大型研究,青少年和年轻成年癌症幸存者的内分泌疾病风险比无癌人群高73%。

哥本哈根丹麦癌症协会研究中心Mette Vestergaard Jensen及其同事研究了从丹麦癌症登记处的32,548名癌症幸存者。

患者在15~39岁时被诊断出癌症。从丹麦民事登记系统中随机选择一个无癌症的188,728名参与者,并与幸存者进行匹配,以便按出生年份和性别进行比较。对于这两个群体,研究人员确定了所有接受了内分泌疾病的出院诊断的住院患者和门诊就诊患者。该研究于1976年~2009年进行,随访时间1977年~2010年进行。

共有2,129名幸存者(6.5%)至少一次去医院就内分泌疾病进行咨询;预计背景人群中有1,232名(3.8%)患者就内分泌疾病进行咨询,导致住院率(RR)显着增加1.73。

甲状腺疾病的最高风险

癌症幸存者患甲状腺疾病的风险最高(占绝对超额风险总数的38%),睾丸功能障碍(17.1%)和2型糖尿病(14.4%)。

内分泌并发症风险最高的群体是白血病,霍奇金淋巴瘤和脑癌的幸存者。

在生物学、流行病学和癌症的临床结果方面,患有癌症的青少年需要不同于儿科癌症患者。研究人员表示,生存率正在急剧上升,青少年面临与癌症或治疗相关的长期发病率。

研究人员表示,每个未来的青少年和青年癌症患者都应该接受最少的有害治疗,以确保癌症后的高质量生活,同时保持良好的治愈率。

这项研究提供了关于这些幸存者的新的,准确的和详细的信息,以及关于如何通过患者因素改变这种晚期效应的风险的重要临床信息。这是识别有内分泌晚期效应风险的患者的第一步,以便可以制定个人概况以评估内分泌疾病的可能风险。

原始出处:

Mette Vestergaard Jensen et al. Endocrine Late Effects in Survivorsof Cancer in Adolescence and Young Adulthood. JAMA Network Open.  2018;1(2):e180349.doi:10.1001/jamanetworkopen.2018.0349

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    2019-04-18 feather89
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createdName=衣带渐宽, createdTime=Wed Jul 04 08:33:34 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329096, encodeId=860432909638, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jul 04 00:34:09 CST 2018, time=2018-07-04, status=1, ipAttribution=)]
    2019-02-04 canlab
  5. 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createdName=衣带渐宽, createdTime=Wed Jul 04 08:33:34 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329096, encodeId=860432909638, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jul 04 00:34:09 CST 2018, time=2018-07-04, status=1, ipAttribution=)]
  6. 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  7. 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2018, time=2018-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567616, encodeId=ce3c156e616cd, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Thu Jul 05 13:58:00 CST 2018, time=2018-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329199, encodeId=245232919924, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Wed Jul 04 08:33:34 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329096, encodeId=860432909638, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jul 04 00:34:09 CST 2018, time=2018-07-04, status=1, ipAttribution=)]
    2018-07-05 liuxiaona
  8. [GetPortalCommentsPageByObjectIdResponse(id=2035734, encodeId=deb32035e34c8, content=<a href='/topic/show?id=1e61489891d' target=_blank style='color:#2F92EE;'>#年轻癌症幸存者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48989, encryptionId=1e61489891d, topicName=年轻癌症幸存者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f7c9348, createdName=neizongke, createdTime=Sun Oct 14 07:58:00 CST 2018, time=2018-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682444, encodeId=48931682444f7, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Sat Dec 15 18:58:00 CST 2018, time=2018-12-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1727419, encodeId=2bed1e27419e8, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Thu Apr 18 12:58:00 CST 2019, time=2019-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1734024, encodeId=1b6b1e34024e4, content=<a href='/topic/show?id=d4f412668a4' target=_blank style='color:#2F92EE;'>#NET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, 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2018, time=2018-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567616, encodeId=ce3c156e616cd, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Thu Jul 05 13:58:00 CST 2018, time=2018-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329199, encodeId=245232919924, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Wed Jul 04 08:33:34 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329096, encodeId=860432909638, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jul 04 00:34:09 CST 2018, time=2018-07-04, status=1, ipAttribution=)]
    2018-07-05 liuxiaona
  9. [GetPortalCommentsPageByObjectIdResponse(id=2035734, encodeId=deb32035e34c8, content=<a href='/topic/show?id=1e61489891d' target=_blank style='color:#2F92EE;'>#年轻癌症幸存者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48989, encryptionId=1e61489891d, topicName=年轻癌症幸存者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f7c9348, createdName=neizongke, createdTime=Sun Oct 14 07:58:00 CST 2018, time=2018-10-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682444, encodeId=48931682444f7, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, 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2018, time=2018-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567616, encodeId=ce3c156e616cd, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Thu Jul 05 13:58:00 CST 2018, time=2018-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329199, encodeId=245232919924, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Wed Jul 04 08:33:34 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329096, encodeId=860432909638, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jul 04 00:34:09 CST 2018, time=2018-07-04, status=1, ipAttribution=)]
    2018-07-04 衣带渐宽

    学习

    0

  10. 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2018, time=2018-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1567616, encodeId=ce3c156e616cd, content=<a href='/topic/show?id=118142341b1' target=_blank style='color:#2F92EE;'>#增高#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42341, encryptionId=118142341b1, topicName=增高)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=af9415191444, createdName=liuxiaona, createdTime=Thu Jul 05 13:58:00 CST 2018, time=2018-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329199, encodeId=245232919924, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmhead/Q3auHgzwzM6P57Bs8gOPaY1cQP9lIia0lmZOEXraGaoicqNToIslXDKw/0, createdBy=7a041951742, createdName=衣带渐宽, createdTime=Wed Jul 04 08:33:34 CST 2018, time=2018-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=329096, encodeId=860432909638, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Wed Jul 04 00:34:09 CST 2018, time=2018-07-04, status=1, ipAttribution=)]
    2018-07-04 明月清辉

    谢谢分享.学习了

    0

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