Diabetes Care:2型糖尿病患者睡眠与HbA1c的关系

2019-11-13 xing.T MedSci原创

由此可见,对于T2D患者睡眠是一个重要的可改变因素。预防失眠可能是T2D患者以睡眠为中心治疗策略的重点。

睡眠不足已被确定为2型糖尿病(T2D)患者血糖控制不佳的危险因素。由于最佳睡眠有多种特征,近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,研究人员评估了哪些睡眠特征与糖化血红蛋白A1c(HbA1c)密切相关。

该研究共有172例T2D患者完成了7天的腕部触觉记录和睡眠调查表。线性回归用于评估睡眠指标(总睡眠时间、睡眠时间长短变异性、午睡时间、午睡时间变异性、睡眠效率、主观睡眠质量和主观失眠症状)与HbA1c之间的关联。

睡眠时间与HbA1c之间的相关性最强(β=0.239;P=0.002;R2=4.9%),其次是总睡眠时间(U形:β=1.161/β2=1.044; P=0.017/0.032; R2=4.3%)、主观睡眠质量(β=0.191; P=0.012; R2=3.6%)、午睡时间变异性(β=0.184;P=0.016;R2=3.4%)和睡眠效率(β=-0.150;R2=2.3%)。睡眠时间和主观失眠症状与HbA1c无关。总的来说,睡眠时间变异性、总睡眠时间和主观睡眠质量与HbA1c显著相关,共同解释了HbA1c10.3%的变异性。校正协变量的分析得到了类似的结果,尽管关联强度通常降低,并且显示总睡眠时间和主观睡眠质量与HbA1c密切相关,它们共同解释了HbA1c6.0%的变异性。

由此可见,对于T2D患者睡眠是一个重要的可改变因素。预防失眠可能是T2D患者以睡眠为中心治疗策略的重点。 

原始出处:

Annelies Brouwer,et al.Sleep and HbA1c in Patients With Type 2 Diabetes: Which Sleep Characteristics Matter Most?.Diabetes Care.2019.https://doi.org/10.2337/dc19-0550

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    2019-12-16 Smile2680
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    2019-11-15 14794e5bm67(暂无昵称)

    学习了,不错的话题,非常精彩,受益非浅

    0

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    2019-11-13 misszhang

    谢谢MedSci提供最新的资讯

    0

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由此可见,根据该研究的发现,应该系统地评估T2D患者VF的患病率。

Circulation:2型糖尿病的新心衰风险评分

2型糖尿病(T2DM)患者心衰的风险增加。钠葡萄糖共转运体抑制剂可降低T2DM患者因心衰的住院率(HHF)。研究人员欲开发和验证一种用于评估T2DM患者HHF临床风险的实用性评分方法,通过评估该评分是否可鉴别具有高风险的T2DM患者是否受益于钠葡萄糖共转运体抑制剂降HHF风险最大。研究人员利用SAVOR-TIMI 53试验对照臂的8212位T2DM患者的数据开发了HHF的临床风险评分。采用多变量C

Circulation:达格列净治疗射血分数降低的心衰患者

2型糖尿病患者的预后试验表明使用钠-葡萄糖共转运体-2抑制剂可降低心力衰竭(HF)的住院率。但这些患者中很少有心衰,而那些有心衰的患者特征不明显。因此,钠-葡萄糖共转运体-2抑制剂用于射血分数降低的心衰患者的效应尚不明确。DEFINE-HF试验(研究达格列净对射血分数降低的心衰患者的生物标志物、症状和功能状态的影响)是一项多中心的随机对照试验,患者的纳入标准为左心室射血分数≤40%、NYHA II

Diabetes Care:氧化损伤的DNA/RNA和8-异前列腺素水平与老年2型糖尿病的发生发展有关

由此可见,大型队列研究的结果支持氧化还原系统失衡导致2型糖尿病的发生发展。但提示这种关联仅在年纪较大时才在临床上变得显著,这可能是由于细胞修复能力降低所致。

Nat Genet:科学家成功解析保护机体抵御2型糖尿病的关键基因功能

日前,一项刊登在国际杂志Nature Genetics上的研究报告中,来自芬兰赫尔辛基大学等机构的科学家们通过研究揭示了一种遗传突变保护机体抵御2型糖尿病的特殊生物学机制;研究者发现,制造锌转运蛋白的基因发生改变会通过增强胰腺分泌胰岛素的方式来降低个体患2型糖尿病的风险。